Publication list



Am. J. Human Genetics


Cancer Research




Clinical Cancer Research




Human Molecular Genetics




Molecular Cell




Nature Cell Biology


Nature Communications


Nature Genetics




New Eng. J. Med.








Proc. Natl. Acad. Sci. USA




Science Translational Medicine








  1. Y. Shindo, S. Hazama, Y. Nakamura, Y. Inoue, S. Kanekiyo,  K. Sakamoto, M. Iida, Y. Tokumitsu, H. Matsui, Y. Watanabe, N. Suzuki, H. Takenouchi, R. Tsunedomi, Y. Maeda, N Maeda, M. Nakashima, T. Ueno, S. Takeda, S. Yoshino, K. Okuno, F. Sugiura, Y. Fujita, Y. Hamamoto, M. Okamoto, T. Fujita, Y. Kawakami, M. Oka, aand H. Nagano:  miR-196b, miR-378a and miR-486 are possible predictive biomarkers for the efficacy of the vaccine treatment; from the results of phase I and II studies for metastatic colorectal cancer. Oncology Letter, in press, 2017
  2. T.H. Mai, A. Takano, H. Suzuki, T. Hirose, T. Mori, K. Teramoto, K. Kiyotani, Y. Nakamura, and Y. Daigo: Quantitative analysis and clonal characterization of T-cell receptor beta repertoires in advanced non-small cell lung cancer patients treated with cancer vaccine treatment. Oncology Letters, in press, 2017
  3. J. Lin, S. Chung, K. Ueda, K. Matsuda, Y. Nakamura, J.-H. Park: GALNT6 stabilizes GRP78 protein by O-glycosylation and enhances its activity to suppress apoptosis under stress condition. Neoplasia, 1943-53, 2017
  4. P. Haycock, S. Burgess, A. Nounu et al.  The association between genetically 1 elevated telomere length and risk of cancer and non-neoplastic diseases. JAMA Oncology, in press, 2017
  5. K. Kiyotani, J.-H. Park, H. Inoue, A. Husain, S. Olugbile, M. Zewde, Y. Nakamura, and W.T. Vigneswaran: Integrated analysis of somatic mutations and immune microenvironment in malignant pleural mesothelioma. Oncoimmunology, in press, 2017
  6. V. Saloura, T. Vougiouklakis, M. Zewde, X. Deng, K. Kiyotani, J.-H. Park, Y. Matsuo, M. Lingen, R. Hamamoto, and Y. Nakamura WHSC1L1-mediated EGFR monomethylation enhances the cytoplasmic and nuclear oncogenic activity of EGFR. Scientific Reports, in press, 2017
  7. J.-H. Park, H. Inoue, T. Kato, M. Zewde, T. Miyamoto, Y. Matsuo, R. Salgia, and Y. Nakamura: TOPK (T–lymphokine-activated killer cell–originated protein kinase) inhibitor exhibits growth suppressive effect on small cell lung cancer. Cancer Science, in press, 2017
  8. W.J. Seow, K. Matsuo, C.A. Hsiung et al.:  Association between GWAS-identified lung adenocarcinoma susceptibility loci and EGFR mutations in never-smoking Asian women, and comparison with findings from Western populations. Human Molecular Genetics, in press, 2017
  9. A. Nagai, M. Hirata, Y. Kamatani, K. Muto, K. Matsuda, Y. Kiyohara, T. Ninomiya, A. Tamakoshi, Z. Yamagata, T. Mushiroda, Y. Murakami, K. Yujil, Y. Furukawa, H. Zembutsu, T Tanaka, Y. Ohnishi, Yusuke Nakamura, BioBank Japan Cooperative Hospital Group, and M. Kubo:  Overview of the BioBank Japan Project: Study design and profile.  Journal of Epidemiology, in press, 2017
  10. M. Hirata, Y. Kamatani, A. Nagai, Y. Kiyohara, T. Ninomiya, A. Tamakoshi, Z. Yamagata, M. Kubo, K. Muto, T. Mushiroda, Y. Murakami, K. Yuji, Y. Furukawa, H. Zembutsu, T. Tanaka, Y. Ohnishio, Y. Nakamura, BioBank Japan Cooperative Hospital Group, and Koichi Matsuda:  Cross-sectional analysis of BioBank Japan clinical data: A large cohort of 200,000 patients with 47 common diseases. Journal of Epidemiology, in press, 2017
  11. M. Hirata, A. Nagai, Y. Kamatani, T. Ninomiya, A. Tamakoshi, Z. Yamagata, M. Kubo, K. Muto, Y. Kiyohara, T. Mushiroda, Y. Murakami, K. Yuji, Y. Furukawa, H. Zembutsu, T. Tanaka, Y. Ohnishi, Y. Nakamura, BioBank Japan Cooperative Hospital Group, and K. Matsuda:  Overview of BioBank Japan follow-up data in 32 diseases. Journal of Epidemiology, in press, 2017
  12. J. Hata, A. Nagai, M. Hirata, Y. Kamatani, A. Tamakoshi, Z. Yamagata, K. Muto, K. Matsuda, M. Kubo, Y. Nakamura, Y. Kiyohara, T. Ninomiya, and Biobank Japan Cooperative Hospital Group:  Risk prediction models for mortality in patients with cardiovascular disease: the BioBank Japan Project. Journal of Epidemiology, in press, 2017
  13. H. Yokomichi, H. Noda, A. Nagai, M. Hirata, Y. Kamatani, Y. Kiyohara, T. Ninomiya, A. Tamakoshi, K. Matsuda, K. Muto, M. Kubo, Y. Nakamura, BioBank Japan Cooperative Hospital Group, and Z. Yamagata:  Cholesterol levels of Japanese dyslipidaemic patients with various comorbidities: BioBank Japan. Journal of Epidemiology, in press, 2017
  14. H. Yokomichi, H. Noda, A. Nagai, M. Hirata, Y. Kamatani, Y. Kiyohara, T. Ninomiya, A. Tamakoshi, K. Matsuda, K. Muto, M. Kubo, Y. Nakamura, BioBank Japan Cooperative Hospital Group, and Z. Yamagata:  Anti-hyperlipidaemic agents and patient mortality: BioBank Japan cohort. Journal of Epidemiology, in press, 2017
  15. H. Yokomichi, H. Noda, A. Nagai, M. Hirata, Y. Kamatani, Y. Kiyohara, T. Ninomiya, A. Tamakoshi, K. Matsuda, K. Muto, M. Kubo, Y. Nakamura, BioBank Japan Cooperative Hospital Group, and Z. Yamagata:  Serum glucose, cholesterol and blood pressure levels in Japanese patients with type 1 and 2 diabetes: BioBank Japan cohort. Journal of Epidemiology, in press, 2017
  16. H. Yokomichi, H. Noda, A. Nagai, M. Hirata, Y. Kamatani, Y. Kiyohara, T. Ninomiya, A. Tamakoshi, K. Matsuda, K. Muto, M. Kubo, Y. Nakamura, BioBank Japan Cooperative Hospital Group, and Z. Yamagata:  Chronic respiratory disease, cancer and smoking in patients with type 2 diabetes: BioBank Japan cohort. Journal of Epidemiology, in press, 2017
  17. S. Ukawa, E. Okada, K. Nakamura, M. Hirata, A. Nagai, Y. Kamatani, Z. Yamagata, Y. Kiyohara, T. Ninomiya, K. Matsuda, K. Muto, M. Kubo, Y. Nakamura, the BioBank Japan Cooperative Hospital Group, and A. Tamakoshi:  Characteristics of patients with liver cancer in the BioBank Japan Project. Journal of Epidemiology, in press, 2017
  18. S. Ukawa, K. Nakamura, E. Okada, M. Hirata, A. Nagai, Y. Kamatani, Z. Yamagata, Y. Kiyohara, T. Ninomiya, K. Matsuda, K. Muto, M. Kubo, Y. Nakamura, the BioBank Japan Cooperative Hospital Group, and A. Tamakoshi:  Clinical and histopathological characteristics of patients with prostate cancer in the BioBank Japan Project. Journal of Epidemiology, in press, 2017
  19. E. Okada, S. Ukawa, K. Nakamura, M. Hirata, A. Nagai, Y. Kamatani, Z. Yamagata, Y. Kiyohara, T. Ninomiya, K. Matsuda, K. Muto, M. Kubo, Y. Nakamura, the BioBank Japan Cooperative Hospital Group, and A. Tamakoshi:  Demographic and lifestyle factors and survival among patients with esophageal and gastric cancer: The Biobank Japan Project. Journal of Epidemiology, in press, 2017


  1. K. Tamura, S. Hazama, R. Yamaguchi, S. Imoto, H. Takenouchi, Y. Inoue, S. Kanekiyo, Y. Shindo, S. Miyano, Y. Nakamura, and K. Kiyotani: Characterization of T cell repertoire in tumor tissues and blood in advanced colorectal cancers through deep T cell receptor sequencing. Oncology Letters, 11:3643-3649, 2016
  2. M. Leisegang, B. Engels, K. Schreiber, P.Y. Yew, K. Kiyotani, C. Idel, A. Arina, J. Duraiswamy, R.R. Weichselbaum, W. Uckert, Y. Nakamura and H. Schreiber:  Eradication of large solid tumors by gene therapy with a T cell receptor targeting a single cancerspecific point mutation. Clinical Cancer Research, :DOI: 10.1158/1078-0432.CCR-15-2361, 2016
  3. H. Alachkar, and Y. Nakamura: Deep Sequencing of the T-cell receptor repertoire in Patients with haplo-cord and matched-donor transplant (review). Chimerism, DOI:10.1080/19381956.2015.1128624, 2016
  4. N. Choudhury, and Y. Nakamura The importance of immunopharmacogenomics in cancer treatment: Patient selection and monitoring for immune checkpoint antibodies  Cancer Science, :DOI: 10.1111/cas.12862, 2016
  5. A. Stefka, S. Keys, J.-H. Park, Y. Matsuo, S. Chung, Y. Nakamura, A.J. Jakubowiak, and S. Rosebeck: Inhibition of maternal embryonic leucine zipper kinase (MELK) is cytotoxic to myeloma cells, overcomes drug resistance, and impairs putative myeloma stem cell replenishment of malignant plasma cells.   Blood Cancer Journal, 6:doi:10.1038/bcj.2016.71, 2016
  6. D. Hertz, , K. Owzar, S. Lessans, C. Wing, C. Jiang, W. Kelly, J. Patel, S. Halabi, Y. Furukawa, H. Wheeler, A. Sibley, C. Lassiter, L. Weisman, D. Watson, S. Krens, F. Mulkey, C. Renn, E. Small, P. Febbo, I. Shterev, D. Kroetz, P. Friedman, J. Mahoney, M. Carducci, M. Kelley, Y. Nakamura, M. Kubo, S. Dorsey, M.E Dolan, M. Morris, M. Ratain, and H. McLeod: Pharmacogenetic discovery in CALGB (Alliance) 90401 and mechanistic validation of a VAC14 polymorphism that increases risk of docetaxel-induced neuropathy. Clinical Cancer Research, :doi: 10.1158/1078-0432.CCR-15-2823 , 2016
  7. Y. Ikeda, K. Kiyotani, P.Y. Yew, T. Kato, K. Tamura, K.-L. Yap, S.M. Nielsen, J.L. Mester, C. Eng, Y. Nakamura, and R.H. Grogan: Germline PARP4 mutations in patients with primary thyroid and breast cancers. Endocrine-Related Cancer, :doi: 10.1530/ERC-15-0359, 2016
  8. J. Mori, C. Tanikawa, Y. Funauchi, P.H.Y. Lo, Y. Nakamura and K. Matsuda Cystatin C as a p53-inducible apoptotic mediator which regulates Cathepsin L activity. Cancer Science, :DOI: 10.1111/cas.12881, 2016
  9. R. Hamamoto, and Yusuke Nakamura: Dysregulation of protein methyltransferases in human cancer: an emerging target class for anticancer therapy. Cancer Science, :DOI: 10.1111/cas.12884, 2016
  10. C.G. Chapman, R. Yamaguchi, K. Tamura, J. Weidner, S. Imoto, J Kwon, H Fang, P.-Y. Yew, S.R. Marino, S. Miyano, Y. Nakamura, and K. Kiyotani: Characterization of T-cell receptor repertoire in inflamed tissues of patients with Crohn’s disease through deep sequencing. Immflamatory Bowel Diseases, :doi: 10.1097/MIB.0000000000000752, 2016
  11. M. Gupta, D. Neavin, D. Liu, J. Biernacka, D. Hall-Flavin, W. Bobo, M. Frye, M. Skime, G. Jenkins, A. Batzler, K. Kalari, W. Matson, S. Bhasin, H. Zhu, T. Mushiroda, Y. Nakamura, M. Kubo, L. Wang, R. Kaddurah-Daouk, and R. Weinshilboum: TSPAN5, ERICH3 and selective serotonin reuptake inhibitors in major depressive disorder: Pharmacometabolomics-informed pharmacogenomics. Molecular Psychiatry, :doi:10.1038/mp.2016.6, 2016
  12. L. Piao, M. Nakakido, T. Suzuki, N. Dohmae, Y. Nakamura and R. Hamamoto:  Automethylation of SUV39H2, an oncogenic histone lysine methyltransferase, regulates its binding affinity to substrate proteins. Oncotarget, :doi: 10.18632/oncotarget.8072, 2016
  13. T. Kato, H. Inoue, S. Imoto, Y. Tamada, T. Miyamoto, Y. Matsuo, Y. Nakamura and J.-H. Park: Oncogenic roles of TOPK and MELK, and effective growth suppression by small molecular inhibitors in kidney cancer cells. Oncotarget, :DOI: 10.18632/oncotarget.7755, 2016
  14. H. Inoue, T. Kato, S. Olugbile, K. Tamura, S. Chung, T. Miyamoto, Y. Matsuo, R. Salgia, Y. Nakamura, and J.-H. Park: Effective growth-suppressive activity of maternal embryonic leucine-zipper kinase (MELK) inhibitor against small cell lung cancer.  Oncotarget, :DOI: 10.18632/oncotarget.7297, 2016
  15. H. Alachkar, N. Fulton, B. Sanford, G. Malnassy, M. Mutonga, R. Larson, C. Bloomfield, G. Marcucci, Y. Nakamura, and W. Stock: Expression and polymorphism (rs4880) of mitochondrial superoxide dismutase (SOD2) and Asparaginase induced hepatotoxicity in adult patients with Acute Lymphoblastic Leukemia. The Pharmacogenomics Journal, :doi:10.1038/tpj.2016.7, 2016
  16. Chung, K. Kijima, A. Kudo, Y. Fujisawa, Y. Harada, A. Taira, N. Takamatsu, T. Miyamoto, Y. Matsuo, and Y. Nakamura: Preclinical evaluation of biomarkers associated with antitumor activity of MELK inhibitor. Oncotarget, :DOI: 10.18632/oncotarget.7685, 2016
  17. N.J. Choudhury, A. Campanile, T. Antic, K.L. Yap, C. Fitzpatrick, J.L. Wade III, T. Karrison, W.M. Stadler, Y. Nakamura, P.H. O’Donnell:  Afatinib activity in platinum-refractory metastatic urothelial carcinoma in patients with ERBB alterations. Journal of Clinical Oncology, :doi: 10.1111/cas.12862, 2016
  18. J.-H. Park, M. Jang, Y.E. Tarhan, T. Katagiri, M. Sasa, Y. Miyoshi, K.R. Kalari, V.J. Suman, R. Weinshilboum, L. Wang,  J.C. Boughey,  M.P. Goetz, and Y. Nakamura: Clonal expansion of anti-tumor T cells in breast cancer correlates with response to neoadjuvant chemotherapy.  International Journal of Oncology, :DOI: 10.3892/ijo.2016.3540, 2016
  19. M. Murahashi, Y. Hijikata, K. Yamada, Y. Tanaka, J. Kishimoto, S. Okano, H. Inoue, T. Marumoto, A. Takahashi, T. Okazaki, K. Takeda, M. Hirakawa, M. Morita, E. Baba, K. Mizumoto, Y. Maehara, M. Tanaka, K. Akashi, Y. Nakanishi, K. Yoshida, T. Tsunoda, K. Tamura, Y. Nakamura, and K. Tani: Phase I clinical trial of a five-peptide cancer vaccine combined with cyclophosphamide in advanced solid tumors. Clinical Immunology,, 2016
  20. Y.E. Tarhan, T. Kato, M. Jang, Y. Haga, K. Ueda, Y. Nakamura, and J.-H. Park: Morphological changes, cadherin switching and growth suppression in pancreatic cancer by GALNT6 knockdown. Neoplasia, 18:265–272, 2016
  21. F.N.G. van ’t Hof , Y.M. Ruigrok, S. Ripke, G. Anderson, M. de Andrade, A.F. Baas, Jan D. Blankensteijn, E.P. Böttinger, M.J. Bown, J. Broderick, P. Bijlenga, D.S. Carrell, D.C. Crawford, D.R. Crosslin, C. Ebeling, J.G. Eriksson, M. Fornage, T. Foroud, M. von und zu Fraunberg, C.M. Friedrich, E.I. Gaál, O. Gottesman, D.-c. Guo, S.C. Harrison, J. Hernesniemi, A. Hofman, I. Inoue, J.E. Jääskeläinen, G.T. Jones, L.A.L.M. Kiemeney, R. Kivisaari, N. Ko, S. Koskinen, M. Kubo, I.J. Kullo, H. Kuivaniemi, M.I. Kurki, A. Laakso, D. Lai, S.M. Leal, H. Lehto, S.A. LeMaire, S.-K. Low, J. Malinowski, C.A. McCarty, D.M. Milewicz, T.H. Mosley, Y. Nakamura, H. Nakaoka, M. Niemelä, J. Pacheco, P.L. Peissig, J. Pera, L. Rasmussen-Torvik, M.D. Ritchie, F. Rivadeneira, A.M. van Rij, R.L.P. Santos-Cortez, A. Saratzis, A. Slowik, A. Takahashi, G. Tromp, A.G. Uitterlinden, S.S. Verma, S.H. Vermeulen, G.T. Wang, Aneurysm Consortium Vascular Research Consortium of New Zealand, G.J.E. Rinkel, P.I.W. de Bakker: Shared genetic risk factors of intracranial, abdominal and thoracic aneurysms. JAHA, :doi: 10.1161/JAHA.115.002603, 2016
  22. V. Saloura, T. Vougiouklakis, M. Zewde, K. Kiyotani, J.-H. Park, G. Gao, T. Karrison, M. Lingen, Y. Nakamura, and R. Hamamoto:  WHSC1L1 drives cell cycle progression through transcriptional regulation of CDC6 and CDK2 in squamous cell carcinoma of the head and neck. Oncotarget, :DOI: 10.18632/oncotarget.989, 2016
  23. T. Kimura, S. Fukushima, A. Miyashita, J. Aoi, M. Jinnin, T. Kosaka, M. Matsukawa, H. Inoue, K. Kiyotani, J.-H. Park, Y. Nakamura, and H. Ihn: Myasthenic crisis and polymyositis induced by one dose of nivolumab.  Cancer Science, 107:1055–1058 (doi: 10.1111/cas.12961), 2016
  24. Y. Ikeda, J.-H. Park, T. Miyamoto, N. Takamatsu, T. Kato, A. Iwasa, S. Okabe, Y. Imai, K. Fujiwara, Y. Nakamura and K. Hasegawa:  T-LAK cell-originated protein kinase (TOPK) as a prognostic factor and a potential therapeutic target in ovarian cancer. Clinical Cancer Research, doi:10.1158/1078-0432.CCR-16-0207, 2016
  25. Y.-M. Chin, L.P. Tan, N.A. Aziz, T. Mushiroda , M. Kubo, N.K.M. Kornain, G.W. Tan, A.S.-B. Khoo, G. Krishnan, K.-C. Pua, Y.-Y. Yap, S.-H. Teo , P.V.-H. Lim, Y. Nakamura, C.L. Lum , The Malaysian NPC Study Group, and C,-C, Ng: Integrated pathway analysis of nasopharyngeal carcinoma implicates the axonemal dynein complex in the Malaysian cohort. International Journal of Cancer, DOI: 10.1002/ijc.30207, 2016
  26. M. Nakakido, K. Tamura, S. Chung, K. Ueda, R. Fujii, K. Kiyotani, and Y. Nakamura:  Phosphatidylinositol glycan anchor biosynthesis, class X containing complex promotes cancer cell proliferation through suppression of EHD2 and ZIC1, putative tumor suppressors. International Journal of Oncology, :doi:  10.3892/ijo.2016.3607, 2016
  27. H. Inoue, J.-H. Park, K. Kiyotani, M. Zewde, A. Miyashita, J. Masatoshi, Y. Kiniwa, R. Okuyama, R. Tanaka, Y. Fujisawa, H. Kato, A. Morita, J. Asai, N. Katoh, K. Yokota, M. Akiyama, H. Ihn, S. Fukushima and Y. Nakamura: Intratumoral expression levels of PD-L1, GZMA, and HLA-A associated with oligoclonal T cell expansion predict response to nivolumab in metastatic melanoma. OncoImmunology,, 2016
  28. T. Nakamura, T. Katagiri, S. Sato, T. Kushibiki, K. Taniuchi, M. Iiizumi, T. Tsuchikawa, S. Hirano and Y. Nakamura: Overexpression of C16orf74 is involved in aggressive pancreatic cancers. Oncotarget, :DOI: 10.18632/oncotarget.10912, 2016
  29. K. Shiraishi, Y. Okada, A. Takahashi, Y. Kamatani, Y. Momozawa, K. Ashikawa, H. Kunitoh, S. Matsumoto, A. Takano, K. Shimizu, A. Goto, K. Tsuta, S. Watanabe, Y. Ohe, Y. Watanabe, Y. Goto, H. Nokihara, K. Furuta, A. Yoshida, K. Goto, T. Hishida, M. Tsuboi, K. Tsuchihara, Y. Miyagi, H. Nakayama, T. Yokose, K. Tanaka, T. Nagashima, Y. Ohtaki, D. Maeda, K. Imai, Y. Minamiya, H. Sakamoto, A. Saito, Y. Shimada, K. Sunami, M. Saito, J. Inazawa, Y. Nakamura, T. Yoshida, J. Yokota, F. Matsuda, K. Matsuo, Y. Daigo, M. Kubo, and T. Kohno: Association of variations in HLA-class II and other loci with susceptibility to EGFR3 mutated lung adenocarcinoma. Nature Communications, :doi:10.1038/ncomms12451, 2016
  30. Y. Yoshioka, T. Suzuki, Y. Matsuo, M. Nakakido, G. Tsurita, C. Simone, T. Watanabe, N. Dohmae, Y. Nakamura and R. Hamamoto:  SMYD3-mediated lysine methylation in the PH domain is critical for activation of AKT1. Oncotarget, :DOI: 10.18632/oncotarget.11898, 2016
  31. W. Obara, T. Karashima, K. Takeda, T. Katagiri, R. Kato, Y. Kato, M. Kanehira, R. Takata, K. Inoue, T. Shuin, Y. Nakamura, and T. Fujioka: Effective induction of cytotoxic T cells recognizing an epitope peptide derived from Hypoxia-Inducible Protein 2 (HIG2) in patients with metastatic renal cell carcinoma.  Cancer Immunology Immunotherapy, :DOI 10.1007/s00262-016-1915-5, 2016
  32. J.-H. Park, S. Chung, Y. Matsuo, and Y. Nakamura:  Development of small molecular compounds targeting cancer stem cells. (Review) MedChemComm, :DOI: 10.1039/c6md00385k, 2016
  33. K.L. Yap, L.V. Furtado, K. Kiyotani, E. Curran, W. Stock, J.L. McNeer, S.Kadri, J. Segal, Y. Nakamura, M.M. Le Beau, S. Gurbuxani, G. Raca: Diagnostic evaluation of RNA sequencing for the detection of genetic abnormalities associated with Ph-like acute lymphoblastic leukemia (ALL). Leukemia & Lymphoma, :DOI: 10.1080/10428194.2016.1219902, 2016
  34. H. Zembutsu, S. Nakamura, S. Akashi-Tanaka, T. Kuwayama, C. Watanabe, T. Takamaru, H. Takei, T. Ishikawa, K Miyahara, H. Matsumoto, Y. Hasegawa, G.Kutomi, H. Shima, F. Satomi, M. Okazaki, H. Zaha, M. Onomura, A. Matsukata, Y. Sagara, S. Baba, A. Yamada, K. Shimada, D. Shimizu, K. Tsugawa, A. Shimo, T.E. Yu, M. Hartman, C.C. Wan, S.C. Lee, and Y. Nakamura: Significant effect of polymorphisms in CYP2D6 on response to tamoxifen therapy for breast cancer; a prospective multicenter study. Clinical Cancer Research, :doi: 10.1158/1078-0432.CCR-16-1779, 2016
  35. K. Kiyotani, T.H. Mai and Y. Nakamura: Comparison of exome-based HLA class I genotyping tools:identification of platform-specific genotyping errors. Journal of Human Genetics, :doi:10.1038/jhg.2016.141, 2016
  36. X. Deng, and Y.Nakamura Cancer precision medicine: from cancer screening to drug selection and personalized immunotherapy. Trends in Pharmacological Sciences,, 2016
  37. N. Suzuki, S. Hazama, H. Iguchi, K. Uesugi, H. Tanaka, K. Hirakawa, A. Aruga, A. Hatori, H. Ishizaki, Y. Umeda, M. Shimada, K. Yoshimatsu, R. Shimizu, H. Hayashi, K. Sakata, H. Takenouchi, H. Matsui, Y. Shindo, M. Iida, H. Koki, H. Arima, H. Furukawa, T. Ueno, S. Yoshino, Y. Nakamura, M. Oka, and H. Nagano: A phase ΙI study of peptides cocktail therapy in combination with gemcitabine as a first-line therapy for advanced pancreatic cancer (VENUS-PC study) Cancer Science, :DOI: 10.1111/cas.13113, 2016
  38. H. Alachkar, M. Mutonga, T. Kato, S. Kalluri; Y. Kakuta, M, Uemura, R, Imamura, N. Nonomura, V. Vujjini, S. Alasfar, H. Rabb, Y. Nakamura, and N. Alachkar: Quantitative characterization of T-cell repertoire and biomarkers in kidney transplant rejection. BMC Nephrology, 17DOI: 10.1186/s12882-016-0395-3, 2016


  1. M.P. Goetz, J.X. Sun, V.J. Suman, G.O. Silva, C.M. Perou, Y. Nakamura, N.J. Cox, P.J. Stephens, V.A. Miller, J.S. Ross, D. Chen, S.L. Safgren, M. Kuffel, M.M. Ames, K.R. Kalari, H. Gomez,  A.M. Gonazalez-Angulo, O. Burgues, H. Brauch, J.N. Ingle, M.J. Ratain, and R. Yelensky: Loss of heterozygosity at the CYP2D6 locus in breast cancer:  Implications for germline pharmacogenetic studies. Journal of National Cancer Insititute, 107:dju401, 2015
  2. P.H.Y. Lo, C. Tanikawa, T. Katagiri, Y. Nakamura, and K. Matsuda: Identification of novel epigenetically inactivated gene PAMR1 in breast carcinoma Oncology Reports, 33:267-273, 2015
  3. R. Hamamoto, V. Saloura and Y. Nakamura: Critical roles of non-histone protein lysine methylation in human tumorigenesis. (review article) Nature Reviews Cancer, 15:110-124, 2015
  4. X. Liu, G. Venkataraman, J. Lin, K. Kiyotani, S. Smith, M. Montoya, Y. Nakamura, and J. Kline: Highly clonal T cell receptor repertoire among regulatory T cells in follicular lymphoma tissues – correlation with the CD8+ T cell receptor repertoire  OncoImmunology, DOI:10.1080/2162402X. 2014.1002728, 2015
  5. N. Thavichachart, T. Mushiroda, T. Thavichachart, O. Charoensook, A. Prasansuklab, P. Rutchatajumroon, S. Tangwongchai, P. Worakul, B. Kanchanatawan, S. Suppapitiporn, A. Sughondhabirom, C. Roomruangwong, W. Chantratita, A. Takahashi, M. Kubo, N. Kamatani, and Y. Nakamura: Genome-wide association study in Thai Tsunami survivors identified risk alleles for posttraumatic stress disorder. Open Journal of Genetics, 5:43-57, 2015
  6. L. Fares-Taie, S. Gerber, A. Tawara, A. Ramirez-Miranda, J.-Y. Douet, H. Verdin, A. Guilloux, J.C. Zenteno, H. Kondo, H. Moisset, B. Passet, K. Yamamoto, M. Iwai, T. Tanaka, Y. Nakamura, W. Kimura, C. Bole-Feysot, M. Vilotte, S. Odent, J.-L. Vilotte, A. Munnich, A. Regnier, N. Chassaing, E. De Baere, I. Raymond-Letron, J. Kaplan, P. Calvas, O. Roche, J.-M. Rozet:  Submicroscopic deletions at 13q32.1 cause congenital microcoria.  Am. J. Human Genetics, 96:631–639, 2015
  7. C.M. Vachon, D.J. Schaid, J.N. Ingle, D.L. Wickerham, M. Kubo, T. Mushiroda, M.P. Goetz, E.E. Carlson, S. Paik, N. Wolmark, Y. Nakamura, L, Wang, R. Weinshilboum, F.J. Couch: A polygenic risk score for breast cancer in women receiving tamoxifen or raloxifene on NSABP P-1 and P-2.  Breast Cancer Research and Treatment, :DOI 10.1007/s10549-014-3175-4, 2015
  8. K. Kusakabe, N. Ide, Y. Daigo, T. Itoh, T. Yamamoto, H. Hashizume, K. Nozu, H. Yoshida, G. Tadano, S. Tagashira, K. Higashino, Y. Okano, Y. Sato, M. Inoue, M. Iguchi, T. Kanazawa, Y. Ishioka, K. Dohi, Y. Kido, S. Sakamoto, S. Ando, M. Maeda, M. Higaki, Y. Baba, and Y. Nakamura:  Discovery of imidazo[1,2-b]pyridazine derivatives: selective and orally available Mps1 (TTK) kinase inhibitors exhibiting remarkable antiproliferative activity. Journal of Medicinal Chemistry, :DOI: 10.1021/jm501599u, 2015
  9. Y. Yoshitake, Y. Nishimura, Y. Nakamura, and M. Shinohara: A clinical trial of multiple peptides vaccination for advanced head and neck cancer patients induced immune responses and prolonged OS (review). OncoImmunology, :DOI:10.1080/2162402X.2015.1022307, 2015
  10. M. Nakakido, Z. Deng, T. Suzuki, N. Dohmae, Y. Nakamura and R. Hamamoto: Dysregulation of AKT pathway by SMYD2-mediated lysine methylation on PTEN. Neoplasia, 17:367–373, 2015
  11. M. Jang, P.-Y. Yew, K. Hasegawa, Y. Ikeda, K. Fujiwara, G.F. Fleming, Y. Nakamura, and J.-H. Park: Characterization of T cell repertoire of blood, tumor and ascites in ovarian cancer patients using next generation sequencing. OncoImmunology, :DOI:10.1080/2162402X.2015.1030561, 2015
  12. T. Vougiouklakis, R. Hamamoto, Y. Nakamura, and V. Saloura:  The NSD family of protein methyltransferases in human cancer. (review) Epigenomics, :doi:10.2217/epi.15.32, 2015
  13. K. Kusakabe, N. Ide, Y. Daigo, T. Itoh, T. Yamamoto, E. Kojima, Y. Mitsuoka, G. Tadano, S. Tagashira, K. Higashino, Y. Okano, Y. Sato, M. Inoue, M. Iguchi, T. Kanazawa, Y. Ishioka, K. Dohi, Y. Kido, S. Sakamoto, S. Ando, M. Maeda, M. Higaki, H. Yoshizawa, H. Murai, and Y. Nakamura: A unique hinge binder of extremely selective aminopyridine-based Mps1 (TTK) kinase inhibitors with cellular activity. Bioorganic & Medicinal Chemistry , 23:2247–2260, 2015
  14. P.Y. Yew, H. Alachkar, R. Yamaguchi, K. Kiyotani, H. Fang, K.L. Yap, H.T. Liu, A. Wickrema, A. Artz, K. van Besien, S. Imoto, S. Miyano, M.R. Bishop, W. Stock, and Y. Nakamura: Quantitative characterization of T cell repertoire in allogeneic hematopoietic stem cell transplant recipients.  Bone Marrow Transplantation, :doi:10.1038/bmt.2015.133, 2015
  15. M. Komatsu, H.E. Wheeler, S. Chung, S.-K. Low, C. Wing, S.M. Delaney, L.K. Gorsic, A. Takahashi, M. Kubo, D.L. Kroetz, W. Zhang, Y. Nakamura, and M.E. Dolan:  Pharmacoethnicity in paclitaxel-Induced sensory peripheral neuropathy. Clinical Cancer Research, :DOI: 10.1158/1078-0432.CCR-15-0133, 2015
  16. X. Deng, G. VonKeudell, T. Suzuki, N. Dohmae, M. Nakakido, L. Piao, Y. Yoshioka, Y Nakamura and R. Hamamoto: PRMT1 promotes mitosis of cancer cells through arginine methylation of INCENP. Oncotarget, :DOI: 10.18632/oncotarget.6050, 2015
  17. L. Piao, T. Suzuki, N. Dohmae, Y. Nakamura and Ryuji Hamamoto: SUV39H2 methylates and stabilizes LSD1 by inhibiting polyubiquitination in human cancer cells. Oncotarget, :doi:  10.18632/oncotarget.4760, 2015
  18. M. Mutonga, K. Tamura, G. Malnassy, N. Fulton, A. de Albuquerque, R. Hamamoto, W. Stock, Y. Nakamura and H. Alachkar: Targeting Suppressor of Variegation 3-9 Homologue 2 (SUV39H2) in acute lymphoblastic leukemia (ALL). Translational Oncology, :doi:10.1016/j.tranon.2015.07.003, 2015
  19. M. Nakakido, Z. Deng, T. Suzuki, N. Dohmae, Y. Nakamura, and R. Hamamoto:  PRMT6 increases cytoplasmic localization of p21CDKN1A in cancer cells through arginine methylation and makes more resistant to cytotoxic agents. Oncotarget, :DOI: 10.18632/oncotarget.5143, 2015
  20. H. Alachkar, M. Mutonga, G. Malnassy, J.-H. Park, N. Fulton, A. Woods, L. Meng, J. Kline, G. Raca, O. Odenike, N. Takamatsu, T. Miyamoto, Y. Matsuo, W. Stock, and Y. Nakamura: T-LAK Cell-Originated Protein Kinase presents a novel therapeutic target in FLT3-ITD mutated Acute Myeloid Leukemia. Oncotarget, :DOI: 10.18632/oncotarget.5418 , 2015
  21. K. Tanakaya, Y. Furukawa, Y. Nakamura, K. Hirata, N. Tomita, K. Tamura, K. Sugano, C. Ishioka, T. Yoshida, H. Ishida, T. Watanabe, and K. Sugihara for HNPCC registry and genetic testing project of the Japanese Society for Cancer of the Colon and Rectum: Relationship between smoking and multiple colorectal cancers in patients with Japanese Lynch syndrome: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. Japanese Journal of Clinical Oncology, :doi:10.1093/jjco/hyu218, 2015
  22. Y. Funauchi, C. Tanikawa, P.H.Y. Lo, J. Mori, Y. Daigo, A. Takano, Y. Miyagi, A. Okawa, Y. Nakamura, and K. Matsuda: Regulation of iron homeostasis by p53-ISCU pathway. Scientific Reports, :doi:  10.1038/srep16497, 2015
  23. N.J. Choudhury, K. Kiyotani, K.L. Yap, A. Campanile, T. Antic, P.Y. Yew, G. Steinberg, J.-H. Park, Y. Nakamura, P.H. O’Donnell: Low T cell receptor diversity, high somatic mutation burden, and high neoantigen load as predictors of clinical outcome in muscle-invasive bladder cancer. European Urology Focus,, 2015
  24. T. Vougiouklakis, K. Sone, V. Saloura, H.-S. Cho, T. Suzuki, N. Dohmae, H. Alachkar, Y. Nakamura and R. Hamamoto: SUV420H1 enhances the phosphorylation and transcription of ERK1 in cancer cells. Oncotarget, :DOI: 10.18632/oncotarget.6351, 2015


  1. A. Chhibber, J. Mefford, E. Stahl, S. Pendergrass, R. Baldwin, K. Owzar, M. Li, E. Winer, C. Hudis, H. Zembutsu, M. Kubo, Y. Nakamura, H. McLeod, M. Ratain, L. Shulman, M. Ritchie, R. Plenge, J. Witte and D. Kroetz:  Polygenic inheritance of paclitaxel-induced sensory peripheral neuropathy driven by axon outgrowth gene sets in CALGB 40101 (Alliance).  The Pharmacogenomics Journal, 14:336–342, 2014
  2. Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, S. Yoshimura, R. Osawa, Y. Kuroda, M. Hirayama, A. Irie, A. Hamada, H. Jono, K.Yoshida, T. Tsunoda, H. Kohrogi, Y. Yoshitake, Y. Nakamura, M. Shinohara, and Y. Nishimura:  Identification of CDCA1 long peptides bearing both CD4+ and CD8+ T-cell epitopes: CDCA1-specific CD4+ T-cell immunity in cancer patients. International Journal of Cancer, 134:352–366, 2014
  3. S. Yoshimura, T. Tsunoda, R. Osawa, M. Harada, T. Watanabe, T. Hikichi, M. Katsuda, M. Miyazawa, M. Tani, M. Iwahashi, K. Takeda, T. Katagiri, Y. Nakamura, and H. Yamaue: Identification of an HLA-A2-restricted epitope peptide derived from hypoxia-inducible protein 2 (HIG2). PLoS ONE, 9:e85267, 2014
  4. K. Yamaguchi, R. Yamaguchi, N. Takahashi, T. Ikenoue, T. Fujii, M. Shinozaki, G. Tsurita, K. Hata, A. Niida, S. Imoto, S. Miyano, Y. Nakamura, and Y. Furukawa: Overexpression of Cohesion Establishment Factor DSCC1 through E2F in Colorectal Cancer. PLoS ONE, 9:e85750, 2014
  5. B. Zhang, W.-H. Jia, K. Matsuo, A. Shin, Y.-B. Xiang, K. Matsuda, S. H. Jee, D.-H. Kim, P. Y. Cheah, Z. Ren, Q. Cai, J. Long, J. Shi, W. Wen, G. Yang, B.-T. Ji, Z.-Z. Pan, F. Matsuda, Y.-T. Gao, J. H. Oh, Y.-O. Ahn, M. Kubo, L. F. Thean, E. J. Park, H.-L. Li, J. W. Park, J. Jo, J.-Y. Jeong, S. Hosono, Y. Nakamura, X.-O. Shu, Y.-X. Zeng, and W. Zheng: Genome-wide association study identifies a new SMAD7 risk variant associated with colorectal cancer risk in East Asians. International Journal of Cancer, 134:DOI: 10.1002/ijc.28733, 2014
  6. J. Lin, Z. Deng, C. Tanikawa, T. Shuin, T. Miki, K. Matsuda, and Y. Nakamura: Downregulation of a tumor suppresser HSPB7, involved in the p53-pathway, in renal cell carcinoma by hypermethylation. International Journal of Oncology, 5:1490-1498, 2014
  7. Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, Y. Kuroda, M. Hirayama, Y. Imamura, J. Yatsuda, M.A. Sayem, A. Irie, A. Hamada, H. Jono, K. Yoshida, T. Tsunoda, Y. Daigo, H. Kohrogi, Y. Yoshitake, Y. Nakamura, M. Shinohara, and Y. Nishimura: LY6K-specific CD4+ T-cell immunity in patients with malignant tumor: Identification of LY6K long peptide encompassing both CD4+ and CD8+ T-cell epitopes. OncoImmunology, 3:DOI: 10.4161/onci.28100, 2014
  8. J.-H. Park, and Y. Nakamura: GALNT6 (UDP-N-acetyl-alpha-D-galactosamine: polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6)) Atlas of Genetic  and Cytpgenetics in Oncology and Hematology, 18:90-92, 2014
  9. Y. Ji, D.J. Schaid, Z. Desta, M. Kubo, A.J. Batzler, K. Snyder, T. Mushiroda, N. Kamatani, E. Ogburn, D. Hall-Flavin, D. Flockhart, Y. Nakamura, D.A. Mrazek, R.M. Weinshilboum: Citalopram and Escitalopram Plasma Drug and Metabolite Concentrations: Genome-Wide Associations. British Journal of Clinical Pharmacology, :DOI: 10.1111/bcp.12348, 2014
  10. L. Piao, D. Kang, T. Suzuki, A. Masuda, N. Dohmae, Y. Nakamura, and R. Hamamoto: The histone methyltransferase SMYD2 methylates PARP1 and promotes poly(ADP-ribosyl)ation activity in cancer cells. Neoplasia, 16:257-264, 2014
  11. S. Hazama, Y. Nakamura, S. Yoshida, Y. Tokuhisa, S. Tomochika, Y. Inoue, N. Suzuki, S. Yoshino, H. Takenouchi, R. Tsunedomi, N. Iizuka, K. Takeda, and M. Oka: A phase Ι study of combination vaccine treatment of five therapeutic epitope-peptides for metastatic colorectal cancer; safety, immunological response, and clinical outcome. Journal of Translational Medicine, 12:63, 2014
  12. H. Iinuma, R. Fukushima, T. Inaba, J. Tamura, T. Inoue, M. Horikawa, E. Ogawa, Y. Ikeda, N. Matsutani, K. Takeda, K. Yoshida, T. Tsunoda, T. Ikeda, Y. Nakamura and K. Okinaga: Phase I clinical study of multiple epitope peptide vaccine combined with chemoradiation therapy in esophageal cancer patients. Journal of Translational Medicine, 12:84, 2014
  13. T. Fujitomo, Y. Daigo, K. Matsuda, K. Ueda and Y. Nakamura: Identification of a nuclear protein, LRRC42, involved in lung carcinogenesis. International Journal of Oncology, 45:147-156, 2014
  14. D. Shigemizu, T. Abe, T. Morizono, T. A. Johnson, K. A. Boroevich, Y. Hirakawa, T. Ninomiya, Y. Kiyohara, M. Kubo, Y. Nakamura, S. Maeda, and T. Tsunoda: The construction of risk prediction models using GWAS data and its application to a type 2 diabetes prospective cohort. PLoS ONE, :DOI: 10.1371/journal.pone.0092549, 2014
  15. A. Yamada, K. Maeda, K. Kiyotani, T. Mushiroda, Y. Nakamura and Y. Sugiyama: Kinetic interaction of the importance of OATP1B3 and MRP2 in docetaxel induced hematopoietic toxicity. Clinical Pharmacology & Therapeutics, 3:e126, 2014
  16. H. Aguilar, A. Urruticoechea, P. Halonen, K. Kiyotani, T. Mushiroda, X. Barril, J. Serra-Musach, A. Isalam, L. Caizzi, L.D. Croce, E. Nevedomskaya, W. Zwart, J. Bostner, E. Karlsson, G.P. Tenorio, T. Fornander, D.C. Sgroi, R. Garcia-Mata, M.P.H.M. Jansen, N. Garcia, N. Bonifaci, F. Climent, M.T. Soler, A. Rodriguez-Vida, M. Gil, J. Brunet, G. Martrat, L. Gomez-Baldo, A.I. Extremera, A. Figueras, J. Balart, R. Clarke, K.L. Burnstein, K.E. Carlson, J.A. Katzenellenbogen, M. Vizoso, M. Esteller, A. Villanueva, A.B. Rodriguez-Peña, X.R. Bustelo, Y. Nakamura, H. Zembutsu, O. Stal, R.L. Beijersbergen and M.A. Pujana: VAV3 mediates resistance to breast cancer endocrine therapy. Breast Cancer Research, 16:doi:10.1186/bcr3664, 2014
  17. M. Hirokawa, H. Morita, T. Tajima, A. Takahashi, K. Ashikawa, F. Miya, D. Shigemizu, K. Ozaki, Y. Sakata, D. Nakatani, S. Suna, Y. Imai, T. Tanaka, T. Tsunoda, K. Matsuda, T. Kadowaki, Y. Nakamura, R. Nagai, I. Komuro, and M. Kubo: A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in Japanese. European Journal of Human Genetics, :doi:10.1038/ejhg.2014.110, 2014
  18. R. Hamamoto, G. Toyokawa, M. Nakakido, K. Ueda, and Y. Nakamura: SMYD2-dependent HSP90 methylation promotes cancer cell proliferation by regulating the chaperone complex formation. Cancer Letters, 351:126–133, 2014
  19. Y. Yamamoto, M. Miyamoto1, D. Tatsuda, M. Kubo, H. Nakagama, Y. Nakamura, H. Satoh, K. Matsuda, T. Watanabe and T. Ohta: A rare polymorphic variant of NBS1 reduces DNA repair activity and elevates chromosomal instability. Cancer Research, :DOI: 10.1158/0008-5472, 2014
  20. H. Fang, X. Liu, J. Ramírez, N. Choudhury, H.K. Im, A. Konkashbaev, N.J. Cox, M.J. Ratain, Y. Nakamura, P.H. O’Donnell: Establishment of CYP2D6 reference samples by multiple validated genotyping platforms.  The Pharmacogenomics Journal, :doi:10.1038/tpj.2014.27, 2014
  21. Y.-M. Chin, T. Mushiroda, A. Takahashi, M. Kubo, G. Krishnan , L.-F. Yap, S.-H. Teo, P. V.-H. Lim, Y.-Y. Yap, K.-C. Pua, N. Kamatani ,Y. Nakamura, C.-K. Sam, A. S.-B. Khoo, The Malaysian NPC Study Group and C.-C. Ng: HLA-A SNPs and amino acid variants are associated with nasopharyngeal 1 carcinoma in Malaysian Chinese. International Journal of Cancer, :DOI: 10.1002/ijc.29035, 2014
  22. S. Hazama, Y. Nakamura, H. Tanaka, K. Hirakawa, K. Tahara, R. Shimizu, H. Ozasa, R. Etoh, F. Sugiura, K. Okuno, T. Furuya, T. Nishimura, K. Sakata, K. Yoshimatsu, H. Takenouchi, R. Tsunedomi, Y. Inoue, S. Kanekiyo, Y. Shindo, N. Suzuki, S. Yoshino, H. Shinozaki, A. Kamiya, H. Furukawa, T. Yamanaka, T. Fujita, Y. Kawakami and M. Oka: A phase ΙI study of five peptides combination with oxaliplatin-based chemotherapy as a first-line therapy for advanced colorectal cancer (FXV study). Journal of Translational Medicine, 12:108, 2014
  23. S. Hazama, H. Takenouchi, R. Tsunedomi, M. Iida, N. Iizuka, Y. Inoue, K. Sakamoto, M. Nakao, Y. Shindo, S. Kanekiyo, Y. Tokumitsu, K. Yoshimura, N. Maeda, K. Maeda, Y. Maeda, H. Matsui, S. Yoshino, Y. Nakamura, Y. Fujita, Y. Hamamoto, M. Okamoto, T. Fujita, Y. Kawakami, and M. Oka: Predictive biomarkers for the outcome of vaccination of five therapeutic epitope peptides for colorectal cancer. Anticancer Research, 34:4201-4206, 2014
  24. M.F. Keller, A.P. Reiner, Y. Okada, F.J.A. van Rooij, A.D. Johnson, M.-H. Chen, A.V. Smith, A.P. Morris, T. Tanaka, L. Ferrucci, A.B. Zonderman, G. Lettre, T. Harris, M. Garcia, S. Bandinelli, R. Qayyum, L.R. Yanek, D.M. Becker, L.C. Becker, C. Kooperberg, B. Keating, J. Reis, H. Tang, E. Boerwinkle, Y. Kamatani, K. Matsuda, N. Kamatani, Y. Nakamura, M. Kubo, S. Liu, A. Dehghan, J.F. Felix, A. Hofman, A.G. Uitterlinden, C.M. van Duijn, O.H. Franco, D.L. Longo, A.B. Singleton, B.M. Psaty, M.K. Evans, L.A. Cupples, J.I. Rotter, C.J. O’Donnell, A. Takahashi, J.G. Wilson, S.K. Ganesh, and M.A. Nalls for the CHARGE Hematology, COGENT, and RIKEN Blood Working Groups: Trans-ethnic meta-analysis of white blood cell phenotypes. Human Molecular Genetics, 23:6944-6960, 2014
  25. Q. Cai, B. Zhang, H. Sung, S.-K. Low, S.-S. Kweon, W. Lu, J. Shi, J. Long, W. Wen, J-Y. Choi, D.-Y. Noh, C.-Y. Shen, K. Matsuo, S.-H. Teo., M.K. Kim, U.S. Khoo, M. Iwasaki, M. Hartman, A. Takahashi, K. Ashikawa, K. Matsuda, M.-H. Shin, M.H. Park, Y. Zheng, Y.-B. Xiang, B.-T. Ji, S.K. Park, P.-E. Wu, C.-N. Hsiung, H. Ito, Y. Kasuga, P. Kang, S. Mariapun, S.H. Ahn, H.S. Kang, K.Y.K. Chan, E.P.S. Man, H. Iwata, S. Tsugane, H. Miao, J. Liao, Y. Nakamura, M. Kubo, The DRIVE GAME-ON Consortium, R.J. Delahanty, Y. Zhang, B. Li, C. Li, Y.-T. Gao, X.-O. Shu, D. Kang, W. Zheng: Genome-wide association analysis in East Asians identifies breast cancer susceptibility loci at 1q32.1, 5q14.3 and 15q26.1. Nature Genetics, 46 :886-890, 2014
  26. B.M. Wolpin, C. Rizzato, P. Kraft, C. Kooperberg, G.M. Petersen, Z. Wang, A.A. Arslan, L. Beane-Freeman, P.M. Bracci, J. Buring, F. Canzian, E.J. Duell, S. Gallinger, G.G. Giles, G.E. Goodman, P.J. Goodman, E.J. Jacobs, A. Kamineni, A.P. Klein, L.N. Kolonel, M.H. Kulke, D. Li, N. Malats, S.H. Olson, H.A. Risch, H.D. Sesso, K. Visvanathan, E. White, W. Zheng, C.C. Abnet, D. Albanes, G. Andriotti, M.A. Austin, R. Barfield, D. Basso, S.I. Berndt, M.-C. Boutron-Ruault, M. Brotzman, M.W. Büchler, H.B. Bueno-de-Mesquita, P. Bugert, L. Burdette, D. Campa, N.E. Caporaso, G. Capurso, C. Chung, M. Cotterchio, E. Costello, J. Elena, N. Funel, J.M. Gaziano, N. Giese, E.L. Giovannucci, M. Goggins, M.J. Gorman, M. Gross, C.A. Haiman, M. Hassan, K. Helzlsouer, B.E. Henderson, E.A. Holly, N. Hu, D.J. Hunter, F. Innocenti, M. Jenab, R. Kaaks, T.J. Key, K.-T. Khaw, E.A. Klein, M. Kogevinas, J. Kupcinskas, R.C. Kurtz, A. LaCroix, M.T. Landi, S. Landi, L.L. Marchand, A. Mambrini, S. Mannisto, R.L. Milne, Y. Nakamura, A.L. Oberg, K. Owzar, S. Panico, A.V. Patel, P.H.M. Peeters, U. Peters, A. Piepoli, M. Porta, F.X. Real, E. Riboli, N. Rothman, A. Scarpa, X.-O. Shu, D.T. Silverman, P. Soucek, M. Sund, R. Talar-Wojnarowska, P.R. Taylor, G.E. Theodoropoulos, M. Thornquist, A. Tjønneland, G.S. Tobias, D. Trichopoulos, P. Vodicka, J. Wactawski-Wende, N. Wentzensen, C. Wu, H. Yu, K. Yu, A. Zeleniuch-Jacquotte, R. Hoover, P. Hartge, C. Fuchs, S. Chanock, R.S. Stolzenberg-Solomon, L. Amundadottir: Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer Nature Genetics, 46:994-1000, 2014
  27. Z. Deng, K. Matsuda, C. Tanikawa, J. Lin, Y. Furukawa, R. Hamamoto and Y. Nakamura:  Late Cornified Envelope Group I, a novel target of p53, regulates PRMT5 activity. Neoplasia, 16:656-664, 2014
  28. K.L. Yap, K. Kiyotani, K. Tamura, T. Antic, M. Jang, M. Montoya, A. Campanile, P.Y. Yew, C. Ganshert, T. Fujioka, G.D. Steinberg, P.H. O’Donnell, and Y. Nakamura: Whole exome sequencing of muscle-invasive bladder cancer identifies recurrent mutations of UNC5C and prognostic importance of DNA repair gene mutations on survival. Clinical Cancer Research, 20: doi: 10.1158/1078-0432.CCR-14-0257, 2014
  29. H. Fang, R. Yamaguchi, X. Liu, Y. Daigo, P.Y. Yew, C. Tanikawa, K. Matsuda, S. Imoto, S. Miyano, and Y. Nakamura: Quantitative T Cell Repertoire Analysis by Deep cDNA Sequencing of T Cell Receptor  and  Chains using Next-Generation Sequencing (NGS) OncoImmunology, :DOI: 10.4161/21624011.2014.968467, 2014
  30. V. Saloura, H.-S. Cho, K. Kyiotani, H. Alachkar, Z. Zuo, M. Nakakido, T. Tsunoda, T. Seiwert, M. Lingen, J. Licht, Y. Nakamura, and R. Hamamoto: WHSC1 Promotes Oncogenesis through Regulation of NIMA-related-kinase-7 in Squamous Cell Carcinoma of the Head and Neck. Molecular Cancer Research, 12:DOI: 10.1158/1541-7786.MCR-14-0292-T, 2014
  31. K. Matsuda, A. Takahashi, W. Obara, Y. Nasu, K. Inoue, K. Tamura, I. Yamasaki, Y. Naya, C. Tanikawa, R. Cui, M. Namiki, Y. Tomita, H. Nishiyama, K. Kohri, T. Deguchi, M. Nakagawa, M. Yokoyama, T. Miki, H. Kumon, T. Fujioka, M. Kubo, Y. Nakamura, and T. Shuin: Genome wide association study identified SNP on 15q24 associated with bladder cancer risk in Japanese population Human Molecular Genetics, :doi: 10.1093/hmg/ddu512, 2014
  32. M. Liu, P.E. Goss, J.N. Ingle, M. Kubo, Y. Furukawa, A. Batzler, G.D. Jenkins, E.E. Carlson, Y. Nakamura, D.J. Schaid, J.-A.W. Chapman, L.E. Shepherd, M.J. Ellis, S. Khosla, L. Wang, and R.M. Weinshilboum: Aromatase Inhibitor-Associated Bone Fractures: A Case-Cohort GWAS and Functional Genomics. Molecular Endocrinology,, 2014
  33. Y. Yamaguchi, H. Yamaue, T. Okusaka, K. Okuno, H. Suzuki, T. Fujioka, A. Otsu, Y. Ohashi, R. Shimazawa, K. Nishio, J. Furuse, H. Minami, T. Tsunoda, Y. Hayashi, and Y. Nakamura, The Committee of Guidance for Peptide Vaccines for the Treatment of Cancer, The Japanese Society for Biological Therapy: Guidance for peptide vaccines for the treatment of cancer. Cancer Science, 105:924-931, 2014
  34. A.C. Wu, B.E. Himes, J. Lasky-Su, A. Litonjua, S.P. Peters, J. Lima, M. Kubo, M. Tamari, Y. Nakamura, W. Qiu, S.T. Weiss, K. Tantisira: Inhaled corticosteroid treatment modulates ZNF432 gene variant’s effect on bronchodilator response in asthmatics. Journal of Allergy and Clinical Immunology, 133:723-728, 2014
  35. Y. Matsuo, J.-H. Park, T. Miyamoto, S. Yamamoto, S. Hisada, H. Alachkar, and Y Nakamura: TOPK inhibitor induces complete tumor regression in xenograft models of human cancer through inhibition of cytokinesis Science Translational Medicine, 259:259ra145, 2014
  36. K. Sone, L. Piao, M. Nakakido, K. Ueda, T. Jenuwein, Y. Nakamura and R. Hamamoto Critical role of lysine 134 methylation on histone H2AX for -H2AX production and DNA repair. Nature Communications, 5:DOI: 10.1038/ncomms6691, 2014
  37. H. Alachkar,  M. Mutonga, K.H. Metzeler, N. Fulton, G. Malnassy, T. Herold, K. Spiekermann, S.K. Bohlander, W. Hiddemann, Y. Matsuo, W. Stock, and Y. Nakamura: Preclinical efficacy of Maternal Embryonic Leucine-zipper Kinase (MELK) Inhibition in Acute Myeloid Leukemia Oncotarget, 512371-12382, 2014
  38. Y. Yoshitake, D. Fukuma, A. Yuno, M. Hirayama, H. Nakayama, T. Tanaka, M. Nagata, Y. Takamune, K. Kawahara, Y. Nakagawa, R. Yoshida, A. Hirosue, H. Ogi, A. Hiraki, H. Jono, A. Hamada, K. Yoshida, Y. Nishimura, Y. Nakamura, and M. Shinohara: Phase II clinical trial of multiple peptide vaccination for advanced head and neck cancer patients revealed induction of immune responses and improved OS. Clinical Cancer Research, DOI: 10.1158/1078-0432. CCR-14-0202, 2014
  39. T. Yamaguchi, T. Yamaguchi, Y. Furukawa, Y. Nakamura, N. Matsubara, H. Ishikawa, M. Arai, N. Tomita, K. Tamura, K. Sugano, C. Ishioka, T. Yoshida, Y. Moriya, H. Ishida, T. Watanabe, and K. Sugihara for HNPCC Registry and Genetic Testing Project of the Japanese Society for Cancer of the Colon and Rectum Comparison of clinical features between suspected familial colorectal cancer type X and Lynch syndrome in Japanese patients with colorectal cancer: a cross-sectional study conducted by the Japanese Society for Cancer of the Colon and Rectum. JJCO, :doi: 10.1093/jjco/hyu190, 2014


  1. A. Köttgen, E. Albrecht, A. Teumer, V. Vitart, J. Krumsiek et al. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations. Nature Genetics, 45:145-154, 2013
  2. H.E. Wheeler, E.R. Gamazon, C. Wing, U.O. Njiaju, C. Njoku, R.M. Baldwin, K. Owzar, C. Jiang, D. Watson, I. Shterev, M. Kubo, H. Zembutsu, E. Winer, C. Hudis, L.N. Shulman, Y. Nakamura, M.J. Ratain, D.L. Kroetz, N.J. Cox, M.E. Dolan for the Cancer and Leukemia Group B:   Integration of cell line and clinical trial genome-wide analyses implicates multiple loci in paclitaxel-induced peripheral neuropathy.   Clinical Cancer Research, 19:491-499, 2013
  3. K. Yamazaki, J. Umeno, A. Takahashi, A. Hirano, T. A. Johnson, N. Kumasaka, T. Morizono, N. Hosono, T. Kawaguchi, M. Takazoe, T. Yamada, Y. Suzuki, H. Tanaka, S. Motoya, M. Hosokawa, Y. Arimura, Y. Shinomura, T. Matsui, T. Matsumoto, M. Iida, T. Tsunoda, Y. Nakamura, N. Kamatani and M. Kubo: A Genome-wide association study Identifies 2 susceptibility loci for Crohn’s disease in a Japanese population. Gastroenterology, 144:781-788, 2013
  4. E.T. Betcheva, A.G. Yosifova, T. Mushiroda, M. Kubo, A. Takahashi, S.K. Karachanak, I.T. Zaharieva, S.P. Hadjidekova, I.I. Dimova, R.V. Vazharova, D.S. Stoyanov, V.K. Milanova, T. Tolev, G. Kirov, N. Kamatani, D.I. Toncheva, and Y. Nakamura: Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene. Psychiatric Genetics, 23:11-19, 2013
  5. D. Kang, H.-S. Cho, G. Toyokawa, M. Kogure, Y. Yamane, Y. Iwai, S. Hayami, T. Tsunoda, H. I. Field, K. Matsuda, D. E. Neal, B. A.J. Ponder, Y. Maehara, Y. Nakamura, and R. Hamamoto: The Histone Methyltransferase Wolf-Hirschhorn Syndrome Candidate 1-like 1 (WHSC1L1) Is Involved in Human Carcinogenesis. Genes Chromosomes and Cancer, 52:126-139, 2013
  6. R. Nakano, T. Maekawa, H. Abe, Y. Hayashida, H. Ochi, T. Tsunoda, H. Kumada, N. Kamatani, Y. Nakamura and K. Chayama: Single-nucleotide polymorphisms in GALNT8 are associated with the response to interferon therapy for chronic hepatitis C. Journal of General Virology, 94:81-89, 2013
  7. Y. Kamada, N. Kinoshita , Y. Tsuchiya, K. Kobayashi, H. Fujii, N. Terao, K. Kamihagi, N. Koyama, S. Yamada, Y. Daigo, Y. Nakamura, N. Taniguchi, E. Miyoshi: Reevaluation of a lectin antibody ELISA kit for measuring fucosylated haptoglobin in various conditions. Clinica Chimica Acta, 417:48-53, 2013
  8. K. Shimane, Y. Kochi, A. Suzuki, Y. Okada, T. Ishii, T. Horita, K. Saito, A. Okamoto, N. Nishimoto, K. Myouzen, M. Kubo, M. Hirakata, T. Sumida, Y. Takasaki, R. Yamada, Y. Nakamura, N. Kamatani and K. Yamamoto: An association analysis of HLA-DRB1 with systemic lupus erythematosus and rheumatoid arthritis in a Japanese population: effects of *09:01 allele on disease phenotypes. Rheumatology, 52:1172-1182, 2013
  9. Y. Urabe, H. Ochi, N. Kato, V. Kumar1, A. Takahashi, R. Muroyama, N. Hosono3, M. Otsuka, R. Tateishi, P. H. Y. Lo, C. Tanikawa, M. Omata, K. Koike, D. Miki, H. Abe, N. Kamatani, J. Toyota, H. Kumada, M. Kubo, K. Chayama, Y. Nakamura, and Koichi Matsuda: A genome-wide association study of HCV induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at MHC region. Journal of Hepatology, 58:875-882, 2013
  10. A. Aarnink, H.J. Garchon, Y. Okada, T. Takahashi, K. Matsuda, M. Kubo, Y. Nakamura, and B, Blancher: Comparative analysis in cynomolgus macaque identifies a novel human MHC locus controlling platelet blood counts independently of BAK1. Journal of Thrombosis and Haemostasis, 11:384-386, 2013
  11. M. Unoki, A. Masuda, N. Dohmae, K. Arita, M. Yoshimatsu, Y. Iwai, Y. Fukui, K. Ueda, R. Hamamoto, M. Shirakawa, H. Sasaki, and Y. Nakamura: Lysyl 5-Hydroxylation, a novel histone modification, by Jumonji domain containing 6 (JMJD6). Journal of Biological Chemistry, 288:6053-6062. , 2013
  12. K. Tomita, M. Sakashita, T. Hirota, S. Tanaka, K. MasuyamaT. Yamada, S. Fujieda, A. Miyatake, N. Hizawa, M. Kubo, Y. Nakamura, and M. Tamari:  Variants in the 17q21 asthma susceptibility locus are associated with allergic rhinitis in the Japanese population. Allergy, 68:92-100, 2013
  13. Y. Kajita, T. Kato Jr, S. Tamaki, M. Furu, R. Takahashi, S. Nagayama, T. Aoyama, H. Nishiyama, E. Nakamura, T. Katagiri, Y. Nakamura, O. Ogawa, and J. Toguchida: The transcription factor Sp3 regulates the expression of a metastasis-related marker of sarcoma, actin filament-associated protein 1-like 1 (AFAP1L1). PLOS ONE, 8:e49709, 2013
  14. B. E. Himes, K. Sheppard, A. Berndt5, A. S. Leme, R. A. Myers, C. R. Gignoux, A. M. Levin8, W. J. Gauderman, J. J. Yang, R. A. Mathias, I. Romieu, D. G. Torgerson, L. A. Roth, S. Huntsman, C. Eng, B. Klanderman, J. Ziniti, J. Senter-Sylvia, S. J. Szefler, R. F. Lemanske, Jr., R. S. Zeiger, R. C. Strunk, F. D. Martinez, H. Boushey, V. M. Chinchilli, E. Israel, D. Mauger, G. H. Koppelman, D. S. Postma, M. A. E. Nieuwenhuis, J. M. Vonk, J. J. Lima, C. G. Irvin, S. P. Peters, M. Kubo, M. Tamari, Y. Nakamura, A. A. Litonjua, K. G. Tantisira, B. A. Raby, E. R. Bleecker, D. A. Meyers, S. J. London, K. C. Barnes, F. D. Gilliland, L. K. Williams, E. G. Burchard, D. L. Nicolae, C. Ober, D. L. DeMeo, E. K. Silverman, B. Paigen, G. Churchill, S. D. Shapiro, and S. T. Weiss:   Integration of Mouse and Human Genome-wide association data identifies KCNIP4 as an asthma gene.  PLOS ONE, 8:e56179, 2013
  15. The AMD Gene Consortium: Seven new loci associated with age-related macular degeneration. Nature Genetics, 45:422-439, 2013
  16. K. Semba, K. Araki, K. Matsumoto, H. Suda, T. Ando, A. Sei, H. Mizuta, K. Takagi, M. Nakahara, M. Muta, G. Yamada, N. Nakagata, A. Iida, S. Ikegawa, Y. Nakamura, M. Araki, K. Abe, and K. Yamamura: Ectopic expression of Ptf1a induces spinal defects, urogenital defects, and anorectal malformations in Danforth’s short tail mice. PLOS Genetics, 9:e1003204, 2013
  17. A, Hirano, K. Yamazaki, J. Umeno, K. Ashikawa, M. Aoki, T. Matsumoto, S. Nakamura, T. Ninomiya, T. Matsui, F. Hirai, T. Kawaguchi, M. Takazoe, H. Tanaka, S. Motoya, Y. Kiyohara, T. Kitazono, Y. Nakamura, N. Kamatani, and M. Kubo:  Associatiion study of 71 European Crohn's disease susceptibility loci in a Japanese population. Inflammatory Bowel Diseases, 19:526–533, 2013
  18. P.H.Y. Lo, Y. Urabe, V. Kumar, C. Tanikawa, K. Koike, N. Kato, D. Miki, K. Chayama, M. Kubo, Y. Nakamura, and  K. Matsuda: Identification of a functional variant in the MICA promoter which regulates MICA expression and increases HCV-related hepatocellular carcinoma risk. PLOS ONE, 8:DOI: 10.1371/journal.pone.0061279, 2013
  19. M. A. Perera,  L. H. Cavallari, N. A. Limdi, E. R. Gamazon, A. Konkashbaev,  R. Daneshjou,   A. Pluzhnikov,  D. C. Crawford,  J. Wang,   N. Liu,   N. Tatonetti,  S. Bourgeois,   H. Takahashi,  Y. Bradford, B. M. Burkley, R. J. Desnick, J. L. Halperin, S. I. Khalifa, T. Y. Langaee, S. A. Lubitz,  E. A. Nutescu, M. Oetjens, M. H. Shahin,  S. R. Patel, H. Sagreiya, M. Tector, K. E. Weck, M. J. Rieder, S. A. Scott, A. H.B. Wu,  J. K. Burmester, M. Wadelius, P. Deloukas,  M. J. Wagner, T. Mushiroda, M. Kubo,  D. M. Roden, N. J. Cox,  R. B. Altman,  T. E. Klein, Y. Nakamura,  J. A. Johnson: Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study. Lancet, 382:790-796, 2013
  20. M. Ishihara, N. Araya, T. Sato, A. Utsunomiya, Y. Yamano, Y. Nakamura, H. Nakagawa, and K. Ueda:  Preapoptotic protease calpain-2 is frequently suppressed in adult T-cell leukemia. Blood, 121:4340-4347, 2013
  21. M. Liu, J. N. Ingle, B. L. Fridley, A. U. Buzdar, M. E. Robson, M. Kubo, L. Wang, A. Batzler, G. D. Jenkins, T. L. Pietrzak, E. E. Carlson, M. P. Goetz, D. W. Northfelt, E. A. Perez, C. V. Williard, D. J. Schaid, Y. Nakamura and R. M. Weinshilboum: TSPYL5 SNPs: Association with Plasma Estradiol Concentrations and Aromatase Expression. Molecular Endocrinology, 27:657-670, 2013
  22. M. Ratain, Y. Nakamura, and N. J. Cox: CYP2D6 genotype and tamoxifen activity:  Understanding interstudy variability in methodological quality.   Clinical Pharmacology & Therapeutics, 94:185-187, 2013
  23. C. Tanikawa, C. Tanikawa, Y. Okada, A. Takahashi, K. Oda, N. Kamatani, M. Kubo, Y. Nakamura, and K. Matsuda:  Genome wide association study of age at menarche in the Japanese population. PLOS ONE, 8:e63821, 2013
  24. M. Kogure, M. Takawa, H.-S. Cho, G. Toyokawa, K. Hayashi, T. Tsunoda, T. Kobayashi, Y. Daigo, M. Sugiyama, Y. Atomi, Y. Nakamura, and R. Hamamoto: Deregulation of the histone demethylase JMJD2A is involved in human carcinogenesis through regulation of the G1/S transition   Cancer Letters, 336:76-84, 2013
  25. J.N. Ingle, M. Liu, D.L. Wickerham, D.J. Schaid, L. Wang, T. Mushiroda, M. Kubo, J.P. Costantino, V.G. Vogel, S. Paik, M.P. Goetz, M.M. Ames, G.D. Jenkins, A. Batzler, E.E. Carlson, D.A. Flockhart, N. Wolmark, Y. Nakamura, and R.M. Weinshilboum: Selective Estrogen Receptor Modulators and Pharmacogenomic Variation in ZNF423 Regulation of BRCA1 Expression: Individualized Breast Cancer Prevention. Cancer Discovery, 3:812-825, 2013
  26. S. Chung, and Y. Nakamura: MELK inhibitor, novel molecular targeted therapeutics for human cancer stem cells (editorial) Cell Cycle, 12:1655-1656, 2013
  27. K. Kiyotani, T. Mushirota, H. Zembutsu, and Y. Nakamura: Important and critical scientific aspects in pharmacogenomics analysis: lessons from controversial results of tamoxifen and CYP2D6 studies. Journal of Human Genetics, 58:327–333, 2013
  28. S.-K. Low , S. Chung, A. Takahashi, H. Zembutsu, T. Mushiroda, M. Kubo and Y. Nakamura: Genome-wide association study of chemotherapeutic agents-induced severe neutropenia/leucopenia for patients in Biobank Japan   Cancer Science, 104:1074-1082, 2013
  29. T. Yasui, A. Okada, Y. Urabe, M. Usami, K. Mizuno, Y. Kubota, K. Tozawa, S. Sasaki,  Y. Higashi, Y. Sato, M. Kubo, Y. Nakamura, K. Matsuda, and K. Kohri:  A replication study for 3 nephrolithiasis loci at 5q35.3, 7p14.3, and 13q14.1 in the Japanese population. Journal of Human Genetics, 58:588-593, 2013
  30. Y. Daigo, A. Takano, K. Teramoto, S. Chung, and Y. Nakamura:  A Systematic Approach to the Development of Novel Therapeutics for Lung Cancer using Genomic Analyses Clinical Pharmacology & Therapeutics, 94:doi:10.1038/clpt.2013.90, 2013
  31. H. Oshita, R. Nishino, A. Takano, T. Fujitomo, M. Aragaki, T. Kato, H. Akiyama, E. Tsuchiya, N. Kohno, Y. Nakamura, and Y. Daigo: RASEF is a novel diagnostic biomarker and a therapeutic target for lung cancer. Molecular Cancer Research, 11:937-951, 2013
  32. Y. Tomita, A. Yuno, H. Tsukamoto, S. Senju, Y. Kuroda, M. Hirayama, A. Irie, K. Kawahara, J. Yatsuda, A. Hamada, H. Jono, K. Yoshida, T. Tsunoda, H. Kohrogi, Y. Yoshitake, Y. Nakamura, M. Shinohara, and Y. Nishimura; Identification of promiscuous KIF20A long peptides bearing both CD4+ and CD8+ T-cell epitopes: KIF20A-specific CD4+ T-cell immunity in patients with malignant tumor. Clinical Cancer Research, 19:4508-4520, 2013
  33. K. Kusakabe, N. Ide, Y. Daigo, Y. Tachibana, T. Itoh, T. Yamamoto, H. Hashizume, Y. Hato, K. Higashino, Y. Okano, Y. Sato, M. Inoue, M. Iguchi, T. Kanazawa, Y. Ishioka, K. Dohi, Y. Kido, S. Sakamoto, K. Yasuo, M. Maeda, M. Higaki, K. Ueda, H. Yoshizawa, Y. Baba, T. Shiota, H. Murai, and Y. Nakamura: Indazole-based Potent and Cell-Active Mps1 Kinase Inhibitors: Rational Design from Pan-Kinase Inhibitor Anthrapyrazolone (SP600125). Journal of Medicinal Chemistry, 56:4343-4356, 2013
  34. H. Saeki, T. Hirota, H. Nakagawa, Y. Tsunemi, T. Kato, S. Shibata, M. Sugaya, S. Sato, S. Doi, A. Miyatake, K. Ebe, E. Noguchi, T. Ebihara, M. Amagai, H. Esaki, S. Takeuchi, M. Furue, Y. Nakamura, and M. Tamari: Genetic polymorphisms in the IL22 gene are associated with psoriasis vulgaris in a Japanese population. Journal of Dermatological Science, 2013
  35. D. Ellinghaus, H. Baurecht, J. Esparza-Gordillo, E. Rodríguez, A. Matanovic, I. Marenholz, N. Hübner, H. Schaarschmidt, N. Novak, S. Michel, L. Maintz, T. Werfel, U. Meyer-Hoffert, M. Hotze, H. Prokisch, K. Heim, C. Herder, T. Hirota, M. Tamari, M. Kubo, A. Takahashi, Y. Nakamura, L. C. Tsoi, P. Stuart, J.T. Elder, L. Sun, X. Zuo, S. Yang, X. Zhang, P. Hoffmann, M. MNöthen, R. Fölster-Holst, J. Winkelmann, T. Illig, B. OBoehm, R. H Duerr, C. Büning, S. Brand, J. Glas, M. A. McAleer, C. M. Fahy, M. Kabesch, S. Brown, W.H.I. McLean, A. DIrvine, S. Schreiber, Y.-A. Lee4, A. Franke and S. Weidinger: High-density genotyping study identifies four new susceptibility loci for atopic dermatitis Nature Genetics, :doi:10.1038/ng.2642, 2013
  36. R. Daneshjou, N. P. Tatonetti, K. J. Karczewski, H. Sagreiya, S. Bourgeois, K. Drozda, J. K. Burmester, T. Tsunoda, Y. Nakamura, M. Kubo, M. Tector, N. A. Limdi, L. H. Cavallari, M. Perera, J. A. Johnson, T. E Klein and R. B. Altman:  Pathway analysis of genome-wide data improves warfarin dose prediction. BMC Genomics, 14:doi:10.1186/1471-2164-14-S3-S11, 2013
  37. T. Yoshimaru, M. Komatsu, T. Matsuo, Y.-A. Chen, Y. Murakami, K. Mizuguchi, E. Mizohata, T. Inoue, M. Akiyama, R. Yamaguchi, S. Imoto, S. Miyano, Y. Miyoshi, M. Sasa, Y. Nakamura, and T. Katagiri:  Targeting BIG3-PHB2 interaction to overcome tamoxifen resistance in breast cancer cells. Nature Communications, 4:DOI: 10.1038/ncomms3443, 2013
  38. S. Chung, S.-K. Low, H. Zembutsu, A. Takahashi, M. Kubo, M. Sasa, and Y. Nakamura: A genome-wide association study of chemotherapy-induced alopecia in breast cancer patients. Breast Cancer Research, 15:R81, 2013
  39. G. Pare, M. Kubo, J. B. Byrd, C. A. McCarty, A. Woodard-Grice, K. K. Teo, S. S. Anand, R L. Zuvich, Y. Bradford, S. Ross, Y. Nakamura, M. Ritchie and N. J. Brown: Genetic variants associated with angiotensin-converting enzyme inhibitor-associated angioedema. Pharmacogenetics and Genomics, 23:470-478, 2013
  40. K. Asano, T. Matsumoto, J. Umeno, A. Hirano, M. Esaki, N. Hosono, T. Matsui, Y. Kiyohara, Y. Nakamura, M. Kubo, and T. Kitazono: Impact of allele copy number of polymorphisms in FCGR3A and FCGR3B genes on susceptibility to ulcerative colitis. Inflammatory Bowel Diseases, 19:2061-2068, 2013
  41. M. A. Province, M. P. Goetz, H. Brauch, D. A. Flockhart, J. M. Hebert, R. Whaley, V. J. Suman, W. Schroth, S. Winter, H. Zembutsu, T. Mushiroda, W. G. Newman, M.-T. M. Lee, C. B. Ambrosone, M. W. Beckmann, J.-Y. Choi, A.-S. Dieudonné, P. A. Fasching, R. Ferraldeschi, L. Gong, E. Haschke-Becher, A. Howell, L. B. Jordan, U. Hamann, K. Kiyotani, P. Krippl, D. Lambrechts, A. Latif, U. Langsenlehner, W. Lorizio, P. Neven, A. T. Nguyen, B.-W. Park, C. A. Purdie, P. Quinlan, W. Renner, M. Schmidt, M. Schwab, J.-G. Shin, J. C. Stingl, P. Wegman, S. Wingren, A. H.B. Wu, E. Ziv, G. Zirpoli, A. M. Thompson, V. C. Jordan, Y. Nakamura, R. B. Altman, M. M. Ames, R. M. Weinshilboum, M. Eichelbaum, J. N. Ingle and T. E. Klein: CYP2D6 Genotype and Adjuvant Tamoxifen: Meta-analysis of Heterogeneous Study Populations. Clinical Pharmacology & Therapeutics, 94:doi: 10.1038/clpt.2013.186, 2013
  42. S.-K. Low, A. Takahashi, K. Ashikawa, J. Inazawa, Y. Miki, M. Kubo, Y. Nakamura, and T. Katagiri: Genome-wide association study of breast cancer in the Japanese population. PLOS ONE, 8:e76463, 2013
  43. K. Ueda, A. Tatsuguchi, N. Saichi, A. Toyama, K. Tamura, M. Furihata, R. Takata, S. Akamatsu, M. Igarashi, M. Nakayama, T. Sato, O. Ogawa, T. Fujioka, T. Shuin, Y. Nakamura, and H. Nakagawa:  Plasma low-molecular-weight proteome profiling identified neuropeptide-Y as a prostate cancer biomarker polypeptide. Journal of Proteome Research, 12:4497-4506, 2013
  44. J. Wang, L. G. Carvajal-Carmona, J.-H. Chu, A. G. Zauber, APC Trial Collaborators, M. Kubo, K. Matsuda, M. Dunlop, R. S. Houlston, O. M. Sieber, L. Lipton, P. Gibbs, N. G. Martin, G. W. Montgomery, J. P. Young, P. N. Baird, M. J. Ratain, Y. Nakamura, S. Weiss, I. Tomlinson, and M. M. Bertagnolli: Germline variants and advanced colorectal adenomas: adenoma Prevention with Celecoxib Trial Genomewide Association Study. Clinical Cancer Research, 19:6430-6437, 2013
  45. C. M. O’Seaghdha, C. M. O’Seaghdha, H. Wu, Q. Yang, K. Kapur, I. Guessous, A. M. Zuber, A. Kottgen, C. Stoudmann, A. Teumer, Z. Kutalik, M. Mangino, A. Dehghan, W. Zhang, G. Eiriksdottir, G. Li, T. Tanaka, L. Portas, L. M. Lopez, C. Hayward, K. Lohman, K. Matsuda, S. Padmanabhan, D. Firsov, R. Sorice, S. Ulivi, A. C. Brockhaus, M. E. Kleber, A. Mahajan, F. D. Ernst, V. Gudnason, L. J. Launer, A. Mace, E. Boerwinckle, D. E. Arking, C. Tanikawa, Y. Nakamura, M. J. Brown, J.-M. Gaspoz, J.-M. Theler, D. S. Siscovick, B. M. Psaty, S. Bergmann, P. Vollenweider, V. Vitart, A. F. Wright, T. Zemunik, M. Boban, I. Kolcic, P. Navarro, E. M. Brown, K. Estrada, J. Ding, T. B. Harris, S. Bandinelli, D. Hernandez, A. B. Singleton, G. Girotto, D. Ruggiero, A. Pio d’Adamo, A. Robino, T. Meitinger, C. Meisinger, G. Davies, J. M. Starr, J. C. Chambers, B. O. Boehm, B. R. Winkelmann, J. Huang, F. Murgia, S. H. Wild, H. Campbell, A. P. Morris, O. H. Franco, A. Hofman, A. G. Uitterlinden, F. Rivadeneira, U. Volker, A. Hannemann, R. Biffar, W. Hoffmann, S.–Y. Shin, P. Lescuyer, H. Henry, C. Schurmann, The SUNLIGHT consortium, The GEFOS consortium, P. B. Munroe, P. Gasparini, N. Pirastu, M. Ciullo, C. Gieger, W. Marz, L. Lind, T. D. Spector, A. V. Smith, I. Rudan, J. F. Wilson, O. Polasek, I. J. Deary, M. Pirastu, L. Ferrucci, Y. Liu, B. Kestenbaum, J. S. Kooner, J. C. M. Witteman, M. Nauck, W. H. L. Kao, H. Wallaschofski, O. Bonny, C. S. Fox, M. Bochud: Meta-analysis of genome-wide association studies identifies six new loci for serum calcium concentrations. PLOS Genetics, 9:e1003796, 2013
  46. M. Kogure, M. Kogure, M. Takawa, V. Saloura, K. Sone, L. Piao, K. Ueda, R. Ibrahim, T. Tsunoda, M. Sugiyama, Y. Atomi, Y. Nakamura and R. Hamamoto:  The oncogenic polycomb histone methyltransferase EZH2 methylates lysine 120 on histone H2B and competes ubiquitination.   Neoplasia, 11:1251-1261, 2013
  47. E.R. Behr, M.D. Ritchie, T. Tanaka, S. Kaab, D.C. Crawford, P. Nicoletti, A. Floratos, M.F. Sinner, P.J. Kannankeril, A.A.M. Wilde, C.R. Bezzina, E. Schulze-Bahr, S. Zumhagen, P. Guicheney, N.H. Bishopric, V. Marshall, S. Shakir, C. Dalageorgou, S. Bevan, Y. Jamshidi, R. Bastiaenen, R.J. Myerburg, J.-J. Schott, A.J. Camm, G. Steinbeck, K. Norris, R.B. Altman, N.P. Tatonetti, S. Jeffery, M. Kubo, Y. Nakamura, Y. Shen, A.L. George, Jr., and D.M. Roden:  Genome wide analysis of drug-Induced Torsades de Pointes: Lack of common variants with large effect sizes. PLOS ONE, 8:e78511, 2013
  48. D. Miki, H. Ochi, A. Takahashi, C.N. Hayes, Y. Urabe, H. Abe, T. Kawaoka, M. Tsuge, N. Hiraga, M. Imamura, Y. Kawakami, H. Aikata, S. Takahashi, N. Akuta, F. Suzuki, K. Ikeda, H. Kumada, Y. Karino, J. Toyota, T. Tsunoda, M. Kubo, N. Kamatani, Y. Nakamura, and K. Chayama: HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: A genome-wide association study Plos ONE, 8e84226, 2013


78 Publications cited >300 times (among 1459 publications (April 1, 2017)

B. Vogelstein, E.R. Fearon, S.R. Hamilton, S. Kern, A.C. Presinger, M. Leppert, Y. Nakamura, R. White, L. Smets and J.L. Bos: Genetic alterations during colorectal tumor development.  New Eng. J. Med., 319:525-532, 1988



The International HapMap Consortium: A haplotype map of the human genome. Nature, 437:1299-1320, 2005


The International HapMap Consortium: The International HapMap Project. Nature, 426:789-796, 2003


The International HapMap Consortium: A second generation human haplotype map of over 3.1 million SNPs. Nature, 449:851-861, 2007


K.W. Kinzler, M.C. Nilbert, L. Su, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, P. Hedge, D. McKechnie, R. Finniear, A. Markham, J. Groffen, M.S. Boguski, S.F. Alschul, A. Horii, H. Ando, Y. Miyoshi, Y. Miki, I. Nishisho, Y. Nakamura: Identification of FAP locus genes from chromosome 5q21. Science, 253:661-665, 1991


S.J. Baker, E.R. Fearon, J.M. Nigro, S.R. Hamilton, A.C. Preisinger, J.M. Jessup, P. vanTuinen, D.H. Ledbetter, D.F. Barker, Y. Nakamura, R. White and B. Vogelstein: Chromosome 17 Deletions and p53 mutations in Colorectal Carcinomas. Science, 244:217-221, 1989


Y. Nakamura, M. Leppert, P. O'Connell, Roger Wolff, T. Holm, M. Culver, C. Martin, E. Fujimoto, M. Hoff, E. Kumlin and R. White: Variable number of tandem repeat (VNTR) markers for human gene mapping. Science, 235:1616-1622, 1987


I. Nishisho, Y. Nakamura, Y. Miyoshi, Y. Miki, H. Ando, A. Horii, K. Koyama, J. Utsunomiya, S. Baba, P. Hedge, A. Markham, A.J. Krush, G. Petersen, S.R. Hamilton, M.C. Nilbert, D.B. Levy, T.M. Bryan, A.C. Preisinger, K.J. Smith, L. Su, K.W. Kinzler, and B. Vogelstein: Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients. Science, 253:665-669, 1991


B. Vogelstein, E.R. Fearon, S.E. Kern, S.R. Hamilton, A.C. Preisinger, Y. Nakamura and R. White: Allelotype of colorectal carcinomas. Science, 244:207-211, 1989


K. Oda, H. Arakawa, T. Tanaka, K. Matsuda, C. Tanikawa, T. Mori, H. Nishimori, K. Tamai, T. Tokino, Y. Nakamura, and Y. Taya: p53AIP1, a potential mediator of p53-dependent apoptosis, and its regulation by Ser-46-phosphorylated p53. Cell, 102:849-862, 2000


The International Warfarin Pharmacogenetics Consortium: Estimation of the warfarin dose with clinical and pharmacogenetic data. New Eng. J. Med., 360:753-764, 2009


P. C. Sabeti, P. Varilly, B. Fry, J. Lohmueller, E. Hostetter, C. Cotsapas, X. Xie, E. H. Byrne, S. A. McCarroll, R. Gaudet, S. F. Schaffner, E. S. Lander, and The International HapMap Consortium: Genome-wide detection and characterization of positive selection in human populations. Nature, 449:913-918, 2007


A. Suzuki, R. Yamada, X. Chang, S.Tokuhiro, T. Sawada, M. Suzuki, M. Nagasaki, M. Nakayama-Hamada, R.Kawaida, M. Ono, M. Ohtsuki, H. Furukawa, S. Yoshino, M. Yukioka, S. Touma, T. Matsubara, S. Wakitani, R. Teshima, A. Sekine, A.Iida, A. Takahashi, T. Tsunoda, Y. Nakamura, and K. Yamamoto: Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis. Nature Genetics, 34:395-402, 2003


C. Larsson, B. Skogseid, K. Obeg, Y. Nakamura, M. Nordenskjold: Multiple endocrine neoplasia type 1 gene maps to chromosome 11 and is lost in insulinoma. Nature, 332:85-87, 1988

The International Cancer Genome Consortium: International network of cancer genome projects. Nature, 464:993-998, 2010




S. Satoh, Y. Daigo, Y. Furukawa, T. Katoh, N. Miwa, T. Nishiwaki, T. Kawasoe, H. Ishiguro, M. Fujita, T. Tokino, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, Y. Yamaoka, and Y. Nakamura: AXIN1 mutations in hepatocellular carcinomas, and growth suppression in cancer cells by virus-mediated transfer of AXIN1. Nature Genetics, 24:245-250, 2000


Y. Miyoshi, H. Nagase, H. Ando, A. Horii, S. Ichii, S. Nakatsuru, T. Aoki, Y. Miki, T. Mori and Y. Nakamura: Somatic mutation of the APC gene in colorectal tumors: mutation cluster region in the APC gene. Human Molecular Genetics, 1:229-233, 1992

H. Tanaka, H. Arakawa, T. Yamaguchi, K. Shiraishi, S. Fukuda, K. Matsui, Y. Takei, and Y. Nakamura: A ribonucleotide reductase gene involved in a p53-dependent cell-cycle checkpoint DNA damage. Nature, 404:42-49, 2000





W. Satake, Y. Nakabayashi, I. Mizuta, Y. Hirota, C. Ito, M. Kubo, T. Kawaguchi, T. Tsunoda, M. Watanabe, A. Takeda, H. Tomiyama, K. Nakashima, K. Hasegawa, F. Obata, T. Yoshikawa, H. Kawakami, S. Sakoda, M. Yamamoto, N. Hattori, M. Murata, Y. Nakamura, and T. Toda: Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease. Nature Genetics, 41:1303-1307, 2009


K. Ozaki, Y. Ohnishi, A. Iida, A. Sekine, R. Yamada, T. Tsunoda, H. Sato, H. Sato, M. Hori, Y. Nakamura, and T. Tanaka: Functional SNPs in the lymphotoxin-α gene that are associated with susceptibility to myocardial infarction. Nature Genetics, 32:650-654, 2002


T. Ota et al.: Complete sequencing and characterization of 21,243 full-length human cDNAs. Nature Genetics, 36:40-45, 2004


D. Barker, E. Wright, K. Nguyen, L. Cannon, P. Fain, D. Goldger, D. T. Bishop, J. Carey, B. Bety, H. Willard, J. S. Waye, G. Greig, L. Leinward, Y. Nakamura, P. O'Connell, M. Leppert, J.-M. Lalouel, R. White and M. Skolnick: Gene for von Recklinghausen neurofibromatosis is in the pericentromeric region of chromosome 17. Science, 236:1100-1102, 1987


K.W. Kinzler, M.C. Nilbert, B. Vogelstein, T.M. Bryan, D.B. Levy, K.J. Smith, A.C. Preisinger, S.R. Hamilton, P. Hedge, A. Merkham, M. Carlson, G. Joslyn, J. Groden, R. White, Y. Miki, I. Nishisho and Y. Nakamura: Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science, 251:1366-1370, 1991


K. Kobayashi, Y. Nakahori, M. Miyake, Y. Nomura, M. Yoshioka, K. Saito, M. Osawa, J. Goto, Y. Nakagome, I. Kanazawa, Y. Nakamura, K. Tokunaga, and T. Toda: An ancient retrotransposal insertion causes Fukuyama-type congenital muscular dystrophy (FCMD). Nature, 394:388-392, 1998


M. Leppert, M. Dobbes, P. Scambler, P. O'Connell, Y. Nakamura, D. Stauffer, S. Woodward, R. Burt, J. Hughes, E. Gardner, M. Lathrop, J. Wasumuth, J.-M. Lalouel, R. White: The gene for familial polyposis coli maps to the long arm of chromosome 5. Science, 238:1411-1413, 1987


R.A. Gatti, I. Berkel, E. Border, G. Braedt, P. Charmley, P. Concannon, F. Ersoy, T. Foroud, N.J.G. Jaspers, K. Lange, G.M. Lathrop, M. Leppert, Y. Nakamura, M. Paterson, W. Salser, O. Sanal, W. Shan, J. Silver, R.S. Sparkes, E. Susi, D. Weeks, R. White and F. Yoder: Localization of ataxia-telangiectasia gene to chromosome 11q22.3. Nature, 336:577-580, 1988


H. Okabe, S. Satoh, T. Kato, O. Kitahara, R. Yanagawa, Y. Yamaoka, T. Tsunoda, Y. Furukawa and Y. Nakamura: Genome-wide analysis of gene expression in human hepatocellular carcinomas using cDNA microarray: identification of genes involved in viral carcinogenesis and tumor progression. Cancer Research, 6:2129-2137, 2001


K. Yasuda, K. Miyake, Y. Horikawa, K. Hara, H. Osawa, H. Furuta, Y. Hirota, H. Mori, A. Jonsson, Y. Sato, K. Yamagata, Y. Hinokio, H.-Y. Wang, T. Tanahashi, N. Nakamura, Y. Oka, N. Iwasaki, Y. Iwamoto, Y. Yamada, Y. Seino, H. Maegawa, A. Kashiwagi, J. Takeda, E. Maeda, H. D. Shin, Y. M. Cho, K. S. Park, H. K. Lee, M. C. Y. Ng, R. C. W. Ma, W.-Y. So, J. C. N. Chan, V. Lyssenko, T. Tuomi, P.Nilsson, L. Groop, N. Kamatani, A. Sekine, Y. Nakamura, K. Yamamoto, T. Yoshida, K. Tokunaga, M. Itakura, H. Makino, K. Nanjo, T. Kadowaki, and M. Kasuga: Variants in KCNQ1 are associated with susceptibility to type 2 diabetes mellitus. Nature Genetics, 40:1092-1097, 2008


R. Hamamoto, Y. Furukawa, M. Morita, Y. Iimura, F. P. Silva, M. Li, R. Yagyu and Y. Nakamura:  SMYD3 encodes a novel histone methyltransferase involved in the proliferation of cancer cells. Nature Cell Biology, 6:731-740, 2004


H. Unoki, A. Takahashi, T. Kawaguchi, K. Hara, M. Horikoshi, G. Andersen, D.P.K. Ng, J. Holmkvist, K. Borch-Johnsen, T. J. Rgensen, A. Sandbaek, T. Lauritzen, T. Hansen, S. Nurbaya, T. Tsunoda, M. Kubo, T. Babazono, H. Hirose, M. Hayashi, Y. Iwamoto, A. Kashiwagi, K. Kaku, R. Kawamori, E. S. Tai, O. Pedersen, N. Kamatani, T. Kadowaki, R. Kikkawa, Y. Nakamura, and S. Maeda: SNPs in KCNQ1 are associated with susceptibility to type 2 diabetes in East Asian and European populations. Nature Genetics, 40:1098-1102, 2008


H. Han, A. Yanagisawa, Y. Kato, J. Park, and Y. Nakamura: Genetic instability in pancreatic cancer and poorly differentiated type of gastric cancer. Cancer Research, 53:5087-5089, 1993


T. Sato, A. Tanigami, K. Yamakawa, F. Akiyama, F. Kasumi, G. Sakamoto and Y. Nakamura: Allelotype of breast cancer: Cumulative allele losses promote tumor progression in primary breast cancer. Cancer Research, 50:7184-7189, 1990


T. Mizuguchi, G. Collod-Beroud, T. Akiyama, M. Abifadel, N. Harada, T. Morisaki, D. Allard, M. Varret, M. Claustres, H. Morisaki, M. Ihara, A. Kinoshita, K. Yoshiura, C. Junien, T. Kajii, G. Jondeau, T. Ohta, T. Kishino, Y. Furukawa, Y. Nakamura, N. Niikawa, C. Boileau, and N. Matsumoto: Heterozygous TGFBR2 mutations in Marfan syndrome. Nature Genetics, 36:855-860, 2004


S. Tokuhiro, R. Yamada, X. Chang, A. Suzuki, Y. Kochi, T. Sawada, M. Suzuki, M. Nagasaki, M. Ohtsuki, M. Ono, H. Furukawa, M. Nagashima, S. Yoshino, A. Mabuchi, A. Sekine, S. Saito, A. Takahashi, T. Tsunoda, Y. Nakamura and K. Yamamoto: An intronic SNP in a RUNX1 binding site of SLC22A4, encoding an organic cation transporter, is associated with rheumatoid arthritis. Nature Genetics, 35:341-348, 2003


Y. Miyoshi, H. Ando, H. Nagase, I. Nishisho, A. Horii, Y. Miki, T. Mori, J. Utsunomiya, S. Baba, G. Petersen, S.R. Hamilton, K.W. Kinzler, B. Vogelstein, Y. Nakamura: Germ-line mutations of the APC gene in 53 familial adenomatous polyposis patients. Proc. Natl. Acad. Sci. USA, 89:4452-4456, 1992


A. Tenesa, S.M. Farrington, J.G.D. Prendergast, M.E. Porteous, M. Walker, N. Haq, R.A. Barnetson, E. Theodoratou, R. Cetnarskyj, N. Cartwright, R. Wilson, C. Semple, A.J. Clarke, F.J.L. Reid, L.A. Smith, K. Kavoussanakis, T. Kossler, P.D.P. Pharoah, S. Buch, C. Schafmayer, J. Tepel, S. Schreiber, H. Volzke, C.O. Schmidt, J. Hampe, S. Wilkening, F. Canzian, J. Chang-Claude, M. Hoffmeister, H. Brenner, G. Capella, V. Moreno, I.J. Deary, J.M. Starr, I.P.M. Tomlinson, E. Webb, R.S. Houlston, G. Rennert, D. Ballinger, L. Rozek, S.B. Gruber, K. Matsuda, T. Kidokoro, Y. Nakamura, B.W. Zanke, C.M.T. Greenwood, J. Rangrej, R. Kustra, A. Montpetit, T.J. Hudson, S. Gallinger, H. Campbell, and M.G. Dunlop:   A genome-wide association scan identifies colorectal cancer susceptibility locus on 11q23 and replicates risk loci at 8q24 and 18q21. Nature Genetics, 40:631-637, 2008

Y. Miyoshi, K. Iwao, Y. Nagasawa, T. Aihara, Y. Sasaki, S. Imaoka, M. Murata, T. Shimano, and Y. Nakamura: Activation of the beta-catenin gene in primary hepatocellular carcinomas by somatic alterations involving exon 3. Cancer Research, 58:2524-2527, 1998








A. Fujimoto, H. Nakagawa, N. Hosono, K. Nakano, T. Abe, K.A. Boroevich, M. Nagasaki, R. Yamaguchi, T. Shibuya, M. Kubo, S. Miyano, Y. Nakamura, and T. Tsunoda: Whole-genome sequencing and comprehensive variant analysis of a Japanese individual using massively parallel sequencing. Nature Genetics, 42:931-936, 2010

S. Kern, E. Fearon, K.W.F. Tersmette, J.P. Enterline, M. Leppert, Y. Nakamura, R. White, B. Vogelstein and S. Hamilton: Allelic loss in colorectal carcinoma. JAMA, 261:3099-3103, 1989





Y. Miki, I. Nishisho, A. Horii, Y. Miyoshi, J. Utsunomiya, K. Kinzler, B. Vogelstein. Y. Nakamura: Disruption of the APC gene by retrotransposal insertion of L1 sequence in a colon cancer. Cancer Research, 52:643-645, 1992


K. Kasai, Y. Nakamura and R. White: Amplification of a VNTR locus (pMCT118) by the polymerase chain reaction (PCR) and its application to forensic science. J. Forensic Sci., 35:1196-1200, 1990


H. Shibata, K. Toyama, H. Shioya, M. Ito, M. Hirota, S. Hasegawa, H. Matsumoto, H. Takano, T. Akiyama, K. Toyoshima, R. Kanamaru, Y. Kanegae, I. Saito, Y. Nakamura, K. Shiba, and T. Noda: Rapid colorectal adenoma formation initiated by conditional targeting of the APC gene. Science, 278:120-123, 1997


N. Hayashi, I. Ito, A. Yanagisawa, Y. Kato, S. Nakamori, S. Imaoka, H. Watanabe, M. Ogawa, and Y. Nakamura: Genetic diagnosis of lymph-node metastasis in colorectal cancer. Lancet, 345:1257-1259, 1995


H. Nagase and Y. Nakamura: Mutations of the APC (adenomatous polyposis coli) gene. Human Mutation, 2:425-434, 1993


K. Yamazaki, D. McGovern, J. Ragoussis, M. Paolucci, H. Butler, D. Jewell, L. Cardon, M. Takazoe, T. Tanaka, T. Ichimori, S. Saito, A. Sekine, A. Iida, A. Takahashi, T. Tsunoda, M. Lathrop and Y. Nakamura: Single nucleotide polymorphisms in TNFSF15 confer susceptibility to Crohn's disease. Human Molecular Genetics, 14:3499-3506, 2005


T. Mori, K. Miura, T. Aoki, T. Nishihira, S. Mori, and Y. Nakamura: Frequent somatic mutation of the MTS1/CDK4I (multiple tumor suppressor/cyclin-dependent kinase 4 inhibitor) gene in esophageal squamous cell carcinoma. Cancer Research, 54:3396-3397, 1994


A. Bourdon, L. Minai, V. Serre, J.-P. Jais, E. Sarzi, S. Aubert, D. Chretien, P. de Lonlay, V. Paquis-Flucklinger, H. Arakawa, Y. Nakamura, A. Munnich, and A. Rotig: Mutation of RRM2B, encoding p53-controlled ribonucleotide reductase (p53R2), causes severe mitochondrial DNA depletion.  Nature Genetics, 39:776-780, 2007


T. Nakatsura, Y. Yoshitake, S. Senju, M. Monji, H. Komori, Y. Motomura, S. Hosaka, T. Beppu, T. Ishiko, H. Kamohara, H. Ashihara, T. Katagiri, Y. Furukawa, S. Fujiyama, M. Ogawa, Y. Nakamura, and Y. Nishimura: Glypican-3, over-expressed specifically in human hepatocellular carcinoma, is a novel tumor marker. Biochemical and Biophysical Research Communications, 306:16-25, 2003


Y. Ohnishi, T. Tanaka, K. Ozaki, R. Yamada, H. Suzuki and Y. Nakamura: A high-throughput SNP typing system for genome-wide association studies. Journal of Human Genetics, 46:471-477, 2001


W. Cookson, R.P. Young, A.J. Sandford, M.F. Moffatt, T. Shirakawa, P.A. Sharp, J.A. Faux, C. Julier, R.A. Wells, P.N. Le Souef, Y. Nakamura, G.M. Lathrop and J.M. Hopkin: Maternal inheritance of atopic IgE responsiveness on chromosome 11q. Lancet, 340:381-384, 1992


K. Ono, T. Tanaka, T. Tsunoda, O. Kitahara, C. Kihara, A. Okamoto, K. Ochiai, T. Takagi, and Y. Nakamura: Identification by cDNA microarray of genes Involved in ovarian carcinogenesis. Cancer Research, 60:5007-5011, 2000


The AMD Gene Consortium: Seven new loci associated with age-related macular degeneration. Nature Genetics, 45:422-439, 2013


M. Leppert, E. Anderson, T. Quattlebaum, D. Stauffer, P. O'Connell, Y. Nakamura, J-M. Lalouel and R. White: Mapping of the seizure gene: Benign familial neonatal convulsions linked to genetic makers on chromosome 20. Nature, 337:647-648, 1989 

Y. Horio, Ta. Takahashi, T. Kuroishi, K. Hibi, M. Suyama, T. Niimi, K. Shimokata, K. Yamakawa, Y. Nakamura, R. Ueda, and To. Takahashi: Prognostic significance of p53 mutation and 3p deletion in primary resected non-small cell lung cancer. Cancer Research, 53:1-4, 1993

H. Kizawa, I. Kou, A. Iida, A. Sudo, Y. Miyamoto, A. Fukuda, A. Mabuchi, A. Kotani, A. Kawakami, S. Yamamoto, N. Uchida, K. Nakamura, K. Notoya, Y. Nakamura and S. Ikegawa: An aspartic acid repeat polymorphism in asporin inhibits chondrogenesis and increases susceptibility to osteoarthritis. Nature Genetics, 37:138-144, 2005







Y. Kamatani, S. Wattanapokayakit, H. Ochi, T. Kawaguchi, A. Takahashi, N. Hosono, M. Kubo, T. Tsunoda, N. Kamatani, H. Kumada, A. Puseenam, T. Sura, Y. Daigo, K. Chayama, W. Chantratita, Y. Nakamura, and K. Matsuda:  A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians. Nature Genetics, 41:591-595, 2009


H. Nagase, Y. Miyoshi, A. Horii, T. Aoki, M. Ogawa, J. Utsunomiya, S. Baba, T. Sasazuki and Y. Nakamura: Correlation between the location of germ-line mutations in the APC gene and the number of colorectal polyps in familial adenomatous polyposis (FAP) patients. Cancer Research, 52:4055-4057, 1992


A.J. Sandford, T. Shirakawa, M.F. Moffatt, S.E. Daniels, C. Ra, J.A. Faux, R.P. Young, Y. Nakamura, G.M. Lathrop, W. Cookson and J.M. Hopkin: Localization of atopy and the βsubunit of  high-affinity IgE receptor (FcERI) on chromosome 11q. Lancet, 341:332-334, 1993


Y. Miyamoto, A. Mabuchi, D. Shi, T. Kubo, Y.  Takatori, S. Saito, M. Fujioka, A. Sudo, A. Uchida, S. Yamamoto, K. Ozaki, M. Takigawa, T. Tanaka, Y. Nakamura, Q. Jiang, and S. Ikegawa: A functional polymorphism in the 5' UTR of GDF5 is associated with susceptibility to osteoarthritis. Nature Genetics, 39:529-533, 2007


A. Okawa, I. Nakamura, S. Goto, H. Moriya, Y. Nakamura, and S. Ikegawa: Mutation in Npps in a mouse model of ossification of the posterior longitudinal ligament of the spine. Nature Genetics, 19:271-273, 1998


A. Niida, T. Hiroko, M. Kasai, Y. Furukawa, Y. Nakamura, Y. Suzuki, S. Sugano and T. Akiyama: DKK1, a negative regulator of Wnt signaling, is a target of the b-catenin/TCF pathway. Oncogene, 23:8520-8526, 2004


O. Kitahara, Y. Furukawa, T. Tanaka, C. Kihara, K. Ono, R. Yanagawa, E. M. Nita, H. Ogasawara, J. Okutsu, H. Zenbutsu, N. Shiraishi, T. Takagi, Y. Nakamura, and T. Tsunoda: Alterations of gene expression during colorectal carcinogenesis revealed by cDNA microarrays after laser-capture microdissection of tumor tissues and normal epithelia. Cancer Research, 61:3544-3549, 2001

Y. Kochi, R. Yamada, A. Suzuki, J. B. Harley, S. Shirasawa, T. Sawada, S. C. Bae, S. Tokuhiro, X. Chang, A. Sekine, A. Takahashi, T. Tsunoda, Y. Ohnishi, K. M. Kaufman, C. P. Kang, C. Kang, S. Otsubo, W. Yumura, A. Mimori, T. Koike, Y. Nakamura, T. Sasazuki and K. Yamamoto: A functional variant in FCRL3, encoding Fc receptor-like 3, is associated with rheumatoid arthritis and several autoimmunities. Nature Genetics, 37:478-485, 2005

S. Chamberlain, J. Shaw, A. Rowland, J. Wallis, S. South, Y. Nakamura, A. von Gabain, M. Farrall and R. Williamson: Mapping of mutation causing Friedrich's ataxia to human chromosome 9. Nature, 334:248-250, 1988

M.H. Jones and Y. Nakamura: Detection of loss of heterozygosity at the human TP53 locus using a dinucleotide repeat polymorphism. Genes Chromosomes and Cancer, 5:89-90, 1992

P.T. Ellinor, K.L. Lunetta, C.M. Albert, N.L. Glazer, M.D. Ritchie, A.V. Smith, D.E. Arking, M. Müller-Nurasyid, B.P. Krijthe, S.A. Lubitz, J.C. Bis, M.K. Chung, K. Ozaki, J.D. Roberts, J.G. Smith, A. Pfeufer, M.F. Sinner, K. Lohman, J. Ding, N.L. Smith, J.D. Smith, M. Rienstra, K.M. Rice, D.R. Van Wagoner, J.W. Magnani, R. Wakili, S. Clauss, J.I. Rotter, G. Steinbeck, L.J. Launer, R.W. Davies, M. Borkovich, T.B. Harris, H. Lin, U. Völker, H. Völzke, D.J. Milan, A. Hofman, E. Boerwinkle, L.Y. Chen, E.Z. Soliman, B.F. Voight, G. Li, A. Chakravarti, M. Kubo, U. Tedrow, L.M. Rse, P.M. Ridker, D. Conen, T. Tsunoda, T. Furukawa, N. Sotoodehnia, S. Xu, N. Kamatani, D. Levy, Y. Nakamura, B. Parvez, S. Mahida, K.L. Furie, J. Rosand, R. Muhammad, B.M. Psaty, T. Meitinger, S. Perz, H.-E. Wichmann, J.C.M. Witteman, W.H.L. Kao, S. Kathiresan, D.M. Roden, A.G. Uitterlinden, F. Rivadeneira, B. McKnight, M. Sjögren, A.B. Newman, Y. Liu, M.H. Gollob, O. Melander, T. Tanaka, B.H.C. Stricker, S.B. Felix, A. Alonso, D. Darbar, J. Barnard, D.I. Chasman, S.R. Heckbert, E.J. Benjamin, V. Gudnason, and S. Kääb: Meta analysis identifies six new susceptibility loci for atrial fibrillation. Nature Genetics, 44:670-688, 2012

M. Unoki and Y. Nakamura: Growth-suppressive effects of BPOZ and EGR2, two genes involved in the PTEN signaling pathway. Oncogene, 20:4457-4465, 2001 

Y. Onouchi, T. Gunji, J. C. Burns, C. Shimizu, J.W. Newburger, M. Yashiro, Yo. Nakamura, H.Yanagawa, K. Wakui, Y. Fukushima, F. Kishi, K. Hamamoto, M. Terai, Y. Sato, K. Ouchi, T. Saji, A. Nariai, Y. Kaburagi, T. Yoshikawa, K. Suzuki, T. Tanaka, T. Nagai, H. Cho, A. Fujino, A. Sekine, R. Nakamichi, T. Tsunoda, T. Kawasaki, Yu. Nakamura and A. Hata: ITPKC functional polymorphism associated with Kawasaki disease susceptibility and formation of coronary artery aneurysms. Nature Genetics, 40:35-42, 2008

M. Emi, Y. Fujiwara, T. Nakajima, E. Tsuchiya, H. Tsuda, S. Hirohashi, M. Miyaki and Y. Nakamura: Frequent loss of heterozygosity for loci on chromosome 8p in hepatocellular carcinoma, colorectal cancer, and lung cancer. Cancer Research, 52:5368-5372, 1992

K. Yamazaki, M. Takazoe, T. Tanaka, T. Ichimori, and Y. Nakamura: Absence of mutation in the NOD2/CARD15 gene among 483 Japanese patients with Crohn's Disease. Journal of Human Genetics, 47:469-472, 2002

T. Kikuchi, Y. Daigo, T. Katagiri, T. Tsunoda, K. Okada, S. Kakiuchi, H. Zembutsu, Y. Furukawa, M. Kawamura, K. Kobayashi, K. Imai, and Y. Nakamura: Expression profiles of non-small cell lung cancers on cDNA microarrays: Identification of genes for prediction of lymph node metastasis and sensitivity to anti-cancer drugs. Oncogene, 22:2192-2205, 2003

Y. Miki, T. Katagiri, F. Kasumi, T. Yoshimoto and Y. Nakamura: Mutation analysis in the BRCA2 gene in primary breast cancers. Nature Genetics, 13:245-247, 1996

T. Ozeki, T. Mushiroda, A. Yowang, A. Takahashi, M. Kubo, Y. Shirakata, Z. Ikezawa, M. Iijima, T. Shiohara, K. Hashimoto, N. Kamatani, and Y. Nakamura: Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in Japanese population.  Human Molecular Genetics, 20:1034-1041, 2011

H. Haga, R. Yamada, Y. Ohnishi, Y. Nakamura, and T. Tanaka: Gene-based SNP discovery as part of the Japanese Millennium Genome Project: identification of 190,562 genetic variations in the human genome. Journal of Human Genetics,47:605-610, 2002

K. Hibi, T. Takahashi, K. Yamakawa, R. Ueda, Y. Sekido, Y. Ariyoshi, M. Suyama, H. Takagi, Y. Nakamura, T. Takahashi: Three distinct regions involved in 3p deletion in human lung cancer. Oncogene, 7:445-449, 1992

S. Matsuura, H. Tauchi, A. Nakamura, N. Kondo, S. Sakamoto, D. Smeets, C. Weemaes, B.H. Belohradsky, M Oshimura, M Isomura, Y. Nakamura and K. Komatsu: Positional cloning of the gene for Nijimegen breakage syndrome. Nature Genetics, 19:179-181, 1998

S. Okamura, H. Arakawa, T. Tanaka, H. Nakanishi, C. C. Ng, Y. Taya, M. Monden, and Y. Nakamura: p53DINP1, a p53-inducible gene, regulates p53-dependent apoptosis. Molecular Cell, 8:85-94, 2001